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Titolo:
Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study
Autore:
Klingberg, T; Vaidya, CJ; Gabrieli, JDE; Moseley, ME; Hedehus, M;
Indirizzi:
Stanford Univ, Dept Psychol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Dept Psychol, Stanford, CA 94305 USA Stanford Univ, Dept Radiol, Stanford, CA 94305 USA Stanford Univ StanfordCA USA 94305 , Dept Radiol, Stanford, CA 94305 USA
Titolo Testata:
NEUROREPORT
fascicolo: 13, volume: 10, anno: 1999,
pagine: 2817 - 2821
SICI:
0959-4965(19990909)10:13<2817:MAOOTF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; ANISOTROPY; GROWTH;
Keywords:
brain development; children; diffusion tensor imaging; diffusion weighted MRI; myelination; white matter; working memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Klingberg, T Stanford Univ, Dept Psychol, Bldg 420, Stanford, CA 94305 USAStanford Univ Bldg 420 Stanford CA USA 94305 rd, CA 94305 USA
Citazione:
T. Klingberg et al., "Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study", NEUROREPORT, 10(13), 1999, pp. 2817-2821

Abstract

MYELINATION is critical for the functional development of the brain, but the time course of myelination during childhood is not well known. Diffusiontensor MR imaging (DTI) provides a new method for estimating myelination in vivo. Myelin restricts diffusion of water transverse to the axons, causing diffusion to be anisotropic. By quantifying the anisotropy, the progressive myelination of axons can be studied. Central white matter of the frontallobe was studied in seven children (mean age 10 years) and five adults (mean age 27 years). Anisotropy in the frontal white matter was significantly lower in children than in adults, suggesting less myelination in children. Measurement of the coherence of white matter revealed that the right frontal lobe had a than the left more regular organization of axons frontal lobe,in both children and adults. The results demonstrate that maturation of the frontal white matter continues into the second decade of life. The time course of prefrontal maturation makes it possible that myelination is a basis for the gradual development of prefrontal functions, such as increased working memory capacity. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 08:46:51