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Titolo:
Decreased type 2 corticotropin-releasing hormone receptor mRNA expression in the ventromedial hypothalamus during repeated immobilization stress
Autore:
Makino, S; Asaba, K; Nishiyama, M; Hashimoto, K;
Indirizzi:
Kochi Med Sch, Dept Internal Med 2, Nankoku, Kochi 783, Japan Kochi Med Sch Nankoku Kochi Japan 783 al Med 2, Nankoku, Kochi 783, Japan
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 3, volume: 70, anno: 1999,
pagine: 160 - 167
SICI:
0028-3835(199909)70:3<160:DT2CHR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y GENE; MESSENGER-RNA EXPRESSION; AGOUTI OBESITY SYNDROME; GLUCOCORTICOID REGULATION; PROOPIOMELANOCORTIN POMC; PARAVENTRICULAR NUCLEUS; RAT HYPOTHALAMUS; LEPTIN ACTION; UROCORTIN; APPETITE;
Keywords:
corticotropin-releasing hormone; corticotropin-releasing hormone receptors; stress; food intake; insulin; leptin; ventromedial nucleus; arcuate nucleus; neuropeptide Y; galanin; pro-opiomelanocortin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Makino, S Kochi Med Sch, Dept Internal Med 2, Nankoku, Kochi 783, Japan Kochi Med Sch Nankoku Kochi Japan 783 Nankoku, Kochi 783, Japan
Citazione:
S. Makino et al., "Decreased type 2 corticotropin-releasing hormone receptor mRNA expression in the ventromedial hypothalamus during repeated immobilization stress", NEUROENDOCR, 70(3), 1999, pp. 160-167

Abstract

Chronic or repeated stress results in reduction of food intake and body weight in rats. Stress-induced anorexia has been attributed to increased corticotropin-releasing hormone (CRH) function in the central nervous system. To explore possible roles of other neuropeptides and peripheral hormones involved in food intake and energy utilization during continuing stress, we examined the impact of repeated immobilization stress on expression of mRNAs coding for CRH, neuropeptide Y (NPY), galanin and pro-opiomelanocortin (POMC) mRNAs in such hypothalamic nuclei as the paraventricular nucleus (PVN), arcuate nucleus (ARC) and dorsomedial hypothalamus (DMH), as well as plasmainsulin and leptin concentrations. Changes in type 2 CRH receptor (CRHR-2)mRNA in the ventromedial hypothalamus (VMH), a possible target of anorectic CRH effect, were also examined. Rats were immobilized for 2 h daily for 6days and sacrificed 24 h after the last immobilization. Immobilized rats had lower food intake and body weight and higher levels of PVN CRH mRNA thancontrols. Repeated immobilization also lowered plasma insulin and leptin concentrations and VMH CRHR-2 mRNA levels. These results provide additional evidence linking VMH CRHR-2 mRNA levels to plasma leptin concentration. ARCNPV and DMH galanin mRNAs increased following repeated immobilization, while ARC POMC mRNA decreased. DMH NPY mRNA and ARC galanin mRNA were unaltered by immobilization. Since NPV and galanin are considered orexigenic, whilethe POMC-melanocortin-4 receptor system is apparently anorexigenic, the changes in neuropeptide mRNAs and VMH CRHR-2 mRNA may play counterregulatory roles against anorectic CRH effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:24:32