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Titolo:
Age-dependent paraparesis in WKA rats: evaluation of MHC k-haplotype and HTLV-1 infection
Autore:
Sun, B; Fang, J; Yagami, K; Kushida, S; Tanaka, M; Uchida, K; Miwa, M;
Indirizzi:
Univ Tsukuba, Inst Basic Med Sci, Dept Biochem & Mol Oncol, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Basic Med Sci, Lab Anim Res Ctr, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 167, anno: 1999,
pagine: 16 - 21
SICI:
0022-510X(19990801)167:1<16:APIWRE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-ASSOCIATED MYELOPATHY; TROPICAL SPASTIC PARAPARESIS; T-CELL LEUKEMIA; VIRUS TYPE-I; MAJOR HISTOCOMPATIBILITY COMPLEX; INTEGRATION; MODEL; LYMPHOCYTES; PROVIRUS;
Keywords:
paraparesis; WKA strain; congenic rat; MHC; RT1; HTLV-1; anti-gag antibody; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Miwa, M Univ Tsukuba, Inst Basic Med Sci, Dept Biochem & Mol Oncol, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 Ibaraki 3058575, Japan
Citazione:
B. Sun et al., "Age-dependent paraparesis in WKA rats: evaluation of MHC k-haplotype and HTLV-1 infection", J NEUR SCI, 167(1), 1999, pp. 16-21

Abstract

Human T-cell leukemia virus type 1 (HTLV-I) infection is shown to be closely associated with HTLV-l-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although the occurrence of HAM/TSP was reported to be associated with MHC class II, the mechanism is still unclear. The WKA(RT1(k)) strain of rats was reported to develop HAM/TSP-like paraparesis after HTLV-I infection, and was suggested to be an animal model of HAM/TSP. We asked whether MHC k-haplotype is specifically involved in the pathogenesis of paraparesis of WKA(RT1(k)) rats. We injected the HTLV-1 producing human T cells (MT-2 cells) intravenously into WKA(RT1(k)) rats and MHC congenic WKA.1L(RT1(k)) rats which have MHC l-haplotype of LEW rats on the WKA background. Positive antibody response to HTLV-I antigens and presence of provirus in peripheral blood mononuclear cells confirmed that MT-2 cell-injected rats were infected with HTLV-1. Two of 13 MT-2 cell-injected WKA(RT1(k)) rats and five of 13 MT-2 cell-injected WKA.1L(RT1(k)) rats developed HAM/TSP-like hindlimbparaparesis between 16 and 26 months old. Interestingly, three of 14 MT-2 cell-uninjected WKA(RT1(k)) rats and four of 13 MT-2 cell-uninjected WKA.1L(RT1(1)) rats showed similar paraparesis between 15 and 26 months old. MHC k-haplotype is not specific to the development of paraparesis in WKA(RT1(k)) rats. The role of aging, genetic background, HTLV-I infection and other factors on the development of HAM/TSP-like paraparesis in rats are discussed. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:36:26