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Titolo:
Histological findings after long-term infusion of intrathecal ketamine forchronic pain: A case report
Autore:
Stotz, M; Oehen, HP; Gerber, H;
Indirizzi:
Kantonsspital, Inst Anesthesiol, CH-4031 Basel, Switzerland KantonsspitalBasel Switzerland CH-4031 siol, CH-4031 Basel, Switzerland Kantonsspital, Inst Pathol, CH-4031 Basel, Switzerland Kantonsspital Basel Switzerland CH-4031 thol, CH-4031 Basel, Switzerland
Titolo Testata:
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
fascicolo: 3, volume: 18, anno: 1999,
pagine: 223 - 228
SICI:
0885-3924(199909)18:3<223:HFALIO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER PAIN; EPIDURAL KETAMINE; MORPHINE; NEUROTOXICITY; INJECTIONS; ANALGESIA; RABBIT;
Keywords:
NMDA-receptor antagonist; ketamine; chronic pain; intrathecal infusion; histopathology; side effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Stotz, M Kantonsspital, Inst Anesthesiol, CH-4031 Basel, Switzerland Kantonsspital Basel Switzerland CH-4031 4031 Basel, Switzerland
Citazione:
M. Stotz et al., "Histological findings after long-term infusion of intrathecal ketamine forchronic pain: A case report", J PAIN SYMP, 18(3), 1999, pp. 223-228

Abstract

(K)etamine, a selective, noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist, is able to alter-pain perception at the spinal level. Lit tie clinical data exist on the intracthecal and epidural use of ketamine in chronic pain. Histopathologic findings after intrathecal injection of ketamine with and without preservatives are rarely reported. This outcome was evaluated in a 72-year-old woman with adominal pain due to cancer. who was treated with the intrathecal application of bupivacaine, clonidine, and morphine. We reached satisfactory pain relief with the addition of ketamine to the mixture for 7 days. On postmortem, focal lymphocytic vasculitis close to the catheter injection site was found. This finding has not been described previously after long-term application of ketamine intrathecally. The intrathecal infusion of ketamine with preservative, or the mixture of ketamine, clonidine, morphine, and bupivacaine resulted in isolated lymphocytic vasculitis of the spinal cord and leptomeninges without any clinical signs of neurological deficit. (C) U.S. Cancer Pain Relief Committee, 1999.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:07:39