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Titolo:
Prevalence and frequency of microembolic signals in 105 patients with extracranial carotid artery occlusive disease
Autore:
Droste, DW; Dittrich, R; Kemeny, V; Schulte-Altedorneburg, G; Ringelstein, EB;
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 4, volume: 67, anno: 1999,
pagine: 525 - 528
SICI:
0022-3050(199910)67:4<525:PAFOMS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL EMBOLIC SIGNALS; STENOSIS; PLAQUE; ENDARTERECTOMY; RISK; MORPHOLOGY; HEMORRHAGE; APPEARANCE; TRIAL;
Keywords:
ultrasonics; carotid artery disease; embolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Droste, DW Univ Munster, Neurol Klin & Poliklin, Dept Neurol, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
D.W. Droste et al., "Prevalence and frequency of microembolic signals in 105 patients with extracranial carotid artery occlusive disease", J NE NE PSY, 67(4), 1999, pp. 525-528

Abstract

Besides the established factors "presence of symptoms" and "degree of stenosis", plaque echolucency is considered to be associated with increased risk of stroke in patients with carotid artery disease. An evaluation was carried out as to whether the prevalence and number of microembolic signals (MES) detected by transcranial Doppler ultrasound were higher in patients withecholucent carotid plaques. One hundred and five patients with carotid artery stenosis from 20%-99% orocclusion underwent clinical investigations, duplex ultrasound of the carotid arteries, and a 1 hour recording from the middle cerebral artery downstream to the carotid artery pathology using the four gate technique. The presence of MES was more frequent and the number greater in symptomatic patients (21 out of 64 patients (33%); mean number of MES in all 64 patients 3.1)than in asymptomatic patients (four out of 41 patients (10%); mean number of MES in all 41 patients 0.3) (p=0.007, and p=0.006, respectively). Echogenicity of the lesions did not affect either number or presence of MES. Positivity for MES and the number of MES increased with increasing degree of stenosis (both p=0.002). Four out of 12 patients with carotid artery occlusion showed MES. No MES could be detected in carotid artery stenosis below 80%. There was a decline in positivity of MES and of the number of MES with the time after the ischaemic event. After 80 days or more after the index event, only one patient showed MES. In conclusion, increasing degree of stenosis and presence of symptoms similarly affect macroembolic and microembolic risk. Thus MES may be a surrogate parameter for risk of stroke. The presence of MES in a few asymptomatic patients suggests that clinically silent circulating microemboli may give additional information on the pending embolic potential of carotid artery stenoses. Echolucency of the plaque was not related to an increased number of MES.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:11:31