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Titolo:
Genetic determination of variation and covariation of peak bone mass at the hip and spine
Autore:
Deng, HW; Stegman, MR; Davies, KM; Conway, T; Recker, RR;
Indirizzi:
Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 teoporosis Res Ctr, Omaha, NE 68178 USA Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ OmahaNE USA 68178 v, Dept Biomed Sci, Omaha, NE 68178 USA
Titolo Testata:
JOURNAL OF CLINICAL DENSITOMETRY
fascicolo: 3, volume: 2, anno: 1999,
pagine: 251 - 263
SICI:
1094-6950(199923)2:3<251:GDOVAC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE-TRAIT LOCI; VITAMIN-D-RECEPTOR; RELATIVE RISK RATIOS; DISCORDANT SIB PAIRS; MINERAL DENSITY; OSTEOPOROTIC FRACTURES; VARIANCE-COMPONENTS; LINKAGE STRATEGY; WHITE WOMEN; ADULT WOMEN;
Keywords:
bone mineral density; peak bone mass; heritability; genetic correlation; common familial environmental effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Deng, HW Creighton Univ, Osteoporosis Res Ctr, 601 N 30th St, Omaha, NE 68178 USA Creighton Univ 601 N 30th St Omaha NE USA 68178 aha, NE 68178 USA
Citazione:
H.W. Deng et al., "Genetic determination of variation and covariation of peak bone mass at the hip and spine", J CLIN DENS, 2(3), 1999, pp. 251-263

Abstract

The likelihood of low trauma fracture in the elderly is highly predictableby peak bone mass (PBM) at age similar to 25-50 yr. We estimated the magnitude of genetic determination of the variation and covariation of PBM of the spine and hip (adjusted by age, gender, and ethnicity) in 47 independent healthy full-sib pairs and 27 healthy mother-offspring pairs. For the spineand hip, the narrow-sense heritabilities (h(2)) (mean +/- SE) were 0.76 +/- 0.34 and 0.84 +/- 0.36, respectively, when estimated from full sibs, and 0.86 +/- 0.38 and 0.84 +/- 0.39, respectively, when estimated from parent-offspring. Some genetic loci underlying PBM variation at the hip and spine are the same or closely linked, as is reflected by the high genetic correlation of 0.95 +/- 0.05 between them when estimated from full sibs, and 0.57 +/- 0.27 when estimated from parent-offspring, respectively. Generally, common familial environmental effects shared by relatives may bias these estimates. However, these effects may be small, since our results reported hereinand those in other earlier studies indicate that common familial environmental effects are probably negligible in causing similarity of bone mass among family members. The correlation of bone mass among randomly sampled couples living in the same household is small and nonsignificant as measured either by densitometry at the radius and ulna or by quantitative ultrasound at the patella. The problem of shared environmental effects notwithstanding,we conclude that much of the PBM Variation and covariation at the hip and spine is determined genetically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 08:11:51