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Titolo:
Angiotensin II and sympathoactivation in heart failure
Autore:
Goldsmith, SR;
Indirizzi:
Hennepin Cty Med Ctr, Div Cardiol, Minneapolis, MN 55415 USA Hennepin Cty Med Ctr Minneapolis MN USA 55415 , Minneapolis, MN 55415 USA Univ Minnesota, Minneapolis, MN USA Univ Minnesota Minneapolis MN USAUniv Minnesota, Minneapolis, MN USA
Titolo Testata:
JOURNAL OF CARDIAC FAILURE
fascicolo: 2, volume: 5, anno: 1999,
pagine: 139 - 145
SICI:
1071-9164(199906)5:2<139:AIASIH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; CARDIAC ADRENERGIC DRIVE; BODY NEGATIVE-PRESSURE; BAROREFLEX CONTROL; CONSCIOUS DOGS; VENTRICULAR DYSFUNCTION; PLASMA NOREPINEPHRINE; CHRONIC INFUSION; HUMAN FOREARM; ARTERIAL;
Keywords:
angiotensin II; catecholamines; heart failure; baroreflexes; sympathetic nervous system; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Goldsmith, SR Hennepin Cty Med Ctr, Div Cardiol, 701 Pk Ave, Minneapolis, MN 55415 USA Hennepin Cty Med Ctr 701 Pk Ave Minneapolis MN USA 55415 USA
Citazione:
S.R. Goldsmith, "Angiotensin II and sympathoactivation in heart failure", J CARD FAIL, 5(2), 1999, pp. 139-145

Abstract

Excessive activity of the sympathetic nervous system (SNS) contributes to the development and progression of the syndrome of congestive heart failure(CHF) in patients with decreased left ventricular function. The factors underlying chronic sympathoactivation are poorly understood, particularly in stable patients. This review summarizes both clinical and experimental dataregarding the effects of angiotensin II (A-II) on the activity of the SNS. The focus is on both the direct effects of A-IT on the SNS and an indirecteffect medicated through alteration in function of the baroreflex. Available evidence is consistent with a potentially important effect of A-II on SNS activity, perhaps most likely via the baroreflex. Important issues regarding the direct effect of A-LT on regional SNS activity, and on the physiological relevance of effects seen only at high plasma concentration of A-II remain to be fully elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:26:45