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Titolo:
Potential of radiation-induced chromosome aberrations to predict radiosensitivity in human tumour cells
Autore:
Martin, JMC; Mooren, E; Ottenheim, C; Burrill, W; Nunez, MI; Sprong, D; Bartelink, H; Begg, AC;
Indirizzi:
Netherlands Canc Inst, Div Expt Therapy, NL-1066 CX Amsterdam, NetherlandsNetherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Dept Radiotherapy, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Paterson Inst Canc Res, Manchester M20 9BX, Lancs, England Paterson Inst Canc Res Manchester Lancs England M20 9BX X, Lancs, England Univ Granada, Dept Radiol & Med Phys, Granada, Spain Univ Granada Granada Spain nada, Dept Radiol & Med Phys, Granada, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
fascicolo: 9, volume: 75, anno: 1999,
pagine: 1161 - 1168
SICI:
0955-3002(199909)75:9<1161:PORCAT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; INDUCED DNA-DAMAGE; INTRINSIC RADIOSENSITIVITY; TRANSLOCATION FREQUENCY; PATIENT RESPONSE; RADIOTHERAPY; CARCINOMA; SURVIVAL; CANCER; REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Begg, AC Netherlands Canc Inst, Div Expt Therapy, Plesmanlaan 121, NL-1066CX Amsterdam, Netherlands Netherlands Canc Inst Plesmanlaan 121 AmsterdamNetherlands NL-1066 CX
Citazione:
J.M.C. Martin et al., "Potential of radiation-induced chromosome aberrations to predict radiosensitivity in human tumour cells", INT J RAD B, 75(9), 1999, pp. 1161-1168

Abstract

Purpose: To validate whether the number of aberrations could be used as a measure of the radiosensitivity of human tumour cells. If so, this would potentially provide a mole rapid method than the colony assay to predict radiocurability in human tumour biopsy material. Materials and methods: A panel of 13 human tumour cell lines was investigated, covering a wide range of radiosensitivities. Fluorescence in situ hybridization (FISH) employing whole chromosome probes was used to detect aberrations. Results: A dose-dependent increase in radiation-induced chromosome aberrations was observed in all cell lines. A good correlation (r = 0.90) was found between cell survival and total chromosome aberrations in 12 of the 13 cell lines (92%), with one exception. A poorer correlation was observed between cell survival and stable- (r = 0.85) and unstable-type aberrations (r = 0.81). Survival-aberration correlations for individual radiation doses wereworse, although statistically significant. The exceptional cell line showed significantly more aberrations for a given level of cell kill than expected based on data for the other lines. Conclusion: This study indicates that radiation-induced chromosome aberrations can be used as a potential predictor of intrinsic radiosensitivity forthe majority of human tumours when more than one dose level is tested. This could aid the design of radiotherapy schedules for each individual patient, or in the decision of whether to use an alternative therapy.

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Documento generato il 13/07/20 alle ore 07:36:33