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Titolo:
The apoptosis-inducing activity of the two protein phosphatase inhibitors,tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A (review)
Autore:
Kikuchi, K; Shima, H; Mitsuhashi, S; Suzuki, M; Oikawa, H;
Indirizzi:
Hokkaido Univ, Inst Immunol Sci, Biochem Sect, Kita Ku, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 oro, Hokkaido 0600815, Japan Hokkaido Univ, Grad Sch Environm Earth Sci, Kita Ku, Sapporo, Hokkaido 0600810, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600810 oro, Hokkaido 0600810, Japan Hokkaido Univ, Fac Agr, Dept Biosci & Chem, Sapporo, Hokkaido 0608589, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608589 oro, Hokkaido 0608589, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 4, volume: 4, anno: 1999,
pagine: 395 - 401
SICI:
1107-3756(199910)4:4<395:TAAOTT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OKADAIC ACID; INDUCTION; TISSUES; POTENT; CELLS;
Keywords:
apoptosis-inducing activity; phosphatase inhibitors; tautomycin; thyrsiferyl 23-acetate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kikuchi, K Hokkaido Univ, Inst Immunol Sci, Biochem Sect, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Kita 15,Nishi 7 Sapporo Hokkaido Japan 0600815 an
Citazione:
K. Kikuchi et al., "The apoptosis-inducing activity of the two protein phosphatase inhibitors,tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A (review)", INT J MOL M, 4(4), 1999, pp. 395-401

Abstract

Thyrsiferyl 23-acetate (TF-23A) has been shown to potently and specifically inhibit PP2A. TF-23A also induced a rapid cell death in various leukemic T- and B-cell lines. The TF-23A induced cell death with a typical apoptoticprocess. TF-23A and its several analogous compounds showed apoptosis-inducing activity. However, only TF-23A out of these compounds showed an inhibitory activity for PP2A. These results suggest that a portion of TF-23A involved in induction of apoptosis is different from that involved in the PP2A inhibition. Then, the effects of tautomycin and its derivatives on PPI and PP2A and their apoptosis-inducing activity were examined. The C-22-C-26 moiety was essential for inhibition of protein phosphatase activity, whereas the C-1-C-18 moiety was essential for induction of apoptosis. Therefore, different moieties of tautomycin are involved in protein phosphatase inhibitionand induction of apoptosis. From these results, it was concluded that the biological effects of phosphatase inhibitors are not necessarily induced bythe inhibition of PP1 and PP2A but through other different molecular mechanisms which remain to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:16:24