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Titolo:
Southwestern Athabaskan (Navajo and Apache) genetic diseases
Autore:
Erickson, RP;
Indirizzi:
Univ Arizona, Coll Med,Dept Pediat, Angel Char Children Wings Genet Res, Steele Mem Childrens Res Ctr,Sect Med & Mol Genet, Tucson, AZ 85724 USA UnivArizona Tucson AZ USA 85724 ct Med & Mol Genet, Tucson, AZ 85724 USA
Titolo Testata:
GENETICS IN MEDICINE
fascicolo: 4, volume: 1, anno: 1999,
pagine: 151 - 157
SICI:
1098-3600(199905/06)1:4<151:SA(AAG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; HERMANSKY-PUDLAK SYNDROME; DYSKERATOSIS CONGENITA; NATIVE-AMERICANS; POPULATION; NEUROPATHY; LINKAGE; LOCALIZATION; ASSIGNMENT; MUTATION;
Keywords:
Navajos; Apaches; neurological disorders; genodermatoses; immunodeficiency; Native Americans; genetic bottlenecks;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Erickson, RP Univ Arizona, Coll Med,Dept Pediat, Angel Char Children WingsGenet Res, Steele Mem Childrens Res Ctr,Sect Med & Mol Genet, 1501 N Campbell Ave,POB 245073, Tucson, AZ 85724 USA Univ Arizona 1501 N Campbell Ave,POB 245073 Tucson AZ USA 85724
Citazione:
R.P. Erickson, "Southwestern Athabaskan (Navajo and Apache) genetic diseases", GENET MED, 1(4), 1999, pp. 151-157

Abstract

Purpose: Four apparently unique disorders are known among the SouthwesternAthabasan Amerindians, i.e., the Navajo and Apache; they are Athabaskan severe combined immunodeficiency, Navajo neuropathy, Navajo poikiloderma, andAthabaskan brainstem dysgenesis. This study reviews background informationon Athabaskan groups and clinical descriptions of these recessive disorders. Methods: The major clinical findings of these four disorders are reviewed. In addition, the findings of epidemiological surveys are included where available. Results: Although the importance of genetic bottlenecks in increasing the frequency of rare, sometimes unique, autosomal recessive disorders is known for a number of populations, similar phenomena among Native Americans seem to be less well known. Conclusion: As many more Native Americansmove off the Reservation, the awareness of susceptibility to particular genetic diseases needs to be more widely disseminated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:56:55