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Titolo:
Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn
Autore:
Kim, JK; Firan, M; Radu, CG; Kim, CH; Ghetie, V; Ward, ES;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Ctr Immunol, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Ctr Canc Immunobiol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr Canc Immunobiol, Dallas, TX 75235 USA Changwon Natl Univ, Dept Microbiol, Changwon, Kyungnam, South Korea Changwon Natl Univ Changwon Kyungnam South Korea , Kyungnam, South Korea
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 9, volume: 29, anno: 1999,
pagine: 2819 - 2825
SICI:
0014-2980(199909)29:9<2819:MTSOHI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-RESIDUES; IMMUNOGLOBULIN-G; HUMAN PLACENTA; CONSTANT-REGION; MICE; LOCALIZATION; MOLECULE; FETAL; SYNCYTIOTROPHOBLAST; TRANSPORTER;
Keywords:
IgG; neonatal Fc receptor; catabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ward, ES Univ Texas, SW Med Ctr, Ctr Immunol, 5323 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 TX 75235 USA
Citazione:
J.K. Kim et al., "Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn", EUR J IMMUN, 29(9), 1999, pp. 2819-2825

Abstract

The analysis of the pharmacokinetics of wild-type and mutated Fc fragmentsderived from human IgG1 indicates that Ile253, His310 and His435 play a central role in regulating serum half-life in mice. Reduced serum half-life of the recombinant, mutated fragments correlates with decreased binding to the MHC class I-related neonatal Fc receptor, FcRn. In addition, the analysis of an Fc fragment in which His435 is mutated to Arg435 demonstrates that the sequence difference at this position between human IgG1 (His435) and IgG3 (Arg435) most likely accounts for the shorter serum half-life of IgG3 relative to IgG1. in contrast to His310 and His435, the data indicate that His433 does not play a role in regulating the serum half-life of human IgG1. Thus, the interaction site of mouse FcRn on human and mouse IgG1 involves the same conserved amino acids located at the CH2-CH3 domain interface of the IgG molecule. The sequence similarities between mouse and human FcRn suggest that these studies have direct relevance to understanding the factors that govern the pharmacokinetics of therapeutic IgG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:52:46