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Titolo:
Six-week treatment with hexarelin in young dogs: evaluation of the GH responsiveness to acute hexarelin or GHRH administration, and of the orexigeniceffect of hexarelin
Autore:
Rigamonti, AE; Cella, SG; Marazzi, N; Muller, EE;
Indirizzi:
Univ Milan, Dept Med Pharmacol, I-20129 Milan, Italy Univ Milan Milan Italy I-20129 Dept Med Pharmacol, I-20129 Milan, Italy
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 141, anno: 1999,
pagine: 313 - 320
SICI:
0804-4643(199909)141:3<313:STWHIY>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; PLASMA GROWTH-HORMONE; SYNTHETIC HEXAPEPTIDE; NEUROPEPTIDE REGULATION; AGED DOGS; FACTOR-I; SECRETAGOGUE; RAT; SECRETION; PITUITARY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, EE Univ Milan, Dept Med Pharmacol, Via Vanvitelli 32, I-20129 Milan, Italy Univ Milan Via Vanvitelli 32 Milan Italy I-20129 Milan, Italy
Citazione:
A.E. Rigamonti et al., "Six-week treatment with hexarelin in young dogs: evaluation of the GH responsiveness to acute hexarelin or GHRH administration, and of the orexigeniceffect of hexarelin", EUR J ENDOC, 141(3), 1999, pp. 313-320

Abstract

In this study we evaluated, in six young (5-7 year-old) beagle dogs, the effects of a 6-week administration of hexarelin (250 mu g/kg s.c. twice daily) on the GH response to an acute challenge with hexarelin or GHRH (2 mu g/kg i.v.), delivered before and after 3 and 6 weeks of treatment. The GH peak response to acute hexarelin or GHRH: initially increased, with a maximum observed at the 3rd week, and then decreased to basal values (GHRH) or less(hexarelin) at the 6th week. These data would indicate that hexarelin initially primed the pituitary to acute administration of further hexarelin or of GHRH, followed by downregulation of the GH response to hexarelin and preservation of the response to GHRH, We then studied the rebound increase in GH secretion after withdrawal of an infusion of somatostatin (4 mu g/kg perh for 1.5 h), a likely stimulus of endogenous GHRH function. The pattern obtained was similar to, though not superimposable upon, that ensuing after acute hexarelin or GHRH administration. Parallel evaluation of the acute orexigenic effect of hexarelin evinced a different timecourse of the behavioural response, namely an acute feeding response to hexarelin that was abolished at the 3rd week and returned to normal at the 6th week. The differing timing of the neuroendocrine or behavioural response to hexarelin would suggest the existence of different subtypes of central nervous system GH-releasing peptide receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:53:49