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Titolo:
The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-beta 1) levels in normal healthy blood donors
Autore:
Young, DG; Skibinski, G; Mason, JI; James, K;
Indirizzi:
Univ Edinburgh, Royal Infirm, Dept Clin & Surg Sci Surg, Lister Res Labs, Edinburgh EH3 9YW, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH3 9YW Midlothian, Scotland Univ Edinburgh, Royal Infirm, Dept Reprod & Dev Sci Clin Biochem, Edinburgh EH3 9YW, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH3 9YW Midlothian, Scotland
Titolo Testata:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
fascicolo: 3, volume: 117, anno: 1999,
pagine: 476 - 481
SICI:
0009-9104(199909)117:3<476:TIOAAG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO PRODUCTION; DEHYDROISOANDROSTERONE SULFATE; CYTOKINE PRODUCTION; MONONUCLEAR-CELLS; POSSIBLE LINKAGE; IMMUNE FUNCTION; AGING PROCESS; INTERLEUKIN-6; MEN; METABOLISM;
Keywords:
ageing; dehydroepiandrosterone sulphate; IL-6; IL-6 soluble receptor; transforming growth factor-beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Young, DG Univ Edinburgh, Royal Infirm, Dept Clin & Surg Sci Surg, Lister Res Labs, Lauriston Pl, Edinburgh EH3 9YW, Midlothian, Scotland Univ Edinburgh Lauriston Pl Edinburgh Midlothian Scotland EH3 9YW
Citazione:
D.G. Young et al., "The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-beta 1) levels in normal healthy blood donors", CLIN EXP IM, 117(3), 1999, pp. 476-481

Abstract

Dysregulation of IL-6 synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, Alzheimer's disease and B cell malignancies. Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone dehydroepiandrosterone (DHEA) and its sulphated derivative DHEA-S. In humans we investigated the relationship between DHEA-S, IL-6,IL-6 sR and TGF-beta 1 in the serum of normal healthy male and female blood donors. Using immunoassay techniques we found that the serum levels of DHEA-S significantly (P = 0.0001) decreased with age in both males and females. Furthermore, mean DHEA-S levels in all age groups were significantly (P = 0.0001) higher-in males. Such correlations were not apparent for IL-6 using a standard assay, but a high sensitivity assay revealed that serum IL-6 was significantly (P=0.0018) positively correlated with age in males only. In addition, serum levels of DHEA-S were significantly (P=0.048) negativelycorrelated with serum IL-6, again in male subjects only. In contrast, serum IL-6 sR and TGF-beta 1 levels were not correlated with age in either males or females and were not significantly different between the sexes. However, a significant (P=0.024) negative correlation between DHEA-S and IL-6 sR was found in males. These studies clearly highlight the complex nature of the relationship between these molecules in the ageing process in normal healthy blood donors and demonstrate the need to use high sensitivity assays when measuring IL-6 in apparently healthy individuals under the age of 70 years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:56:16