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Titolo:
Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [C-11]raclopride?: PET studies combined with microdialysis in conscious monkeys
Autore:
Tsukada, H; Nishiyama, S; Kakiuchi, T; Ohba, H; Sato, K; Harada, N;
Indirizzi:
Hamamatsu Photon, Cent Res Lab, Shizuoka 4348601, Japan Hamamatsu Photon Shizuoka Japan 4348601 Res Lab, Shizuoka 4348601, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 841, anno: 1999,
pagine: 160 - 169
SICI:
0006-8993(19990911)841:1-2<160:ISDCTE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; STRIATAL DOPAMINE; ENDOGENOUS DOPAMINE; C-11 RACLOPRIDE; UNANESTHETIZED MONKEYS; IN-VIVO; N-METHYLSPIPERONE; RECEPTOR-BINDING; H-3 RACLOPRIDE; RHESUS-MONKEY;
Keywords:
dopamine; dopamine D-2 receptor; [C-11]raclopride; positron emission tomography; microdialysis; monkey brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Tsukada, H Hamamatsu Photon, Cent Res Lab, 5000 Hirakuchi, Shizuoka 4348601, Japan Hamamatsu Photon 5000 Hirakuchi Shizuoka Japan 4348601 , Japan
Citazione:
H. Tsukada et al., "Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [C-11]raclopride?: PET studies combined with microdialysis in conscious monkeys", BRAIN RES, 841(1-2), 1999, pp. 160-169

Abstract

The effects of dopamine release manipulated by drugs on the in vivo binding of [C-11]raclopride in the striatum were evaluated in conscious monkeys combined with microdialysis. The in vivo binding of [C-11]raclopride was evaluated by high resolution positron emission tomography (PET), and the dopamine concentrations in the striatal extracellular fluid (ECF) were measured by microdialysis in the same animals. The systemic administration of the direct dopamine enhancers, GBR12909 (a dopamine transporter (DAT) blocker, at0.5, 2 and 5 mg/kg) or methamphetamine (a dopamine releaser, at 0.1, 0.3 and 1 mg/kg) dose-dependently increased the dopamine concentration in the striatal ECF, and decreased in vivo [C-11]raclopride binding in the striatum. The administration of the indirect dopamine modulators benztropine (a muscarinic cholinergic antagonist, at 0.1, 0.3 and 1 mg/kg) or ketanserine (a 5-HT2 antagonist, at 0.3, 1 and 3 mg/kg) also increased dopamine level in the striatal ECF, and decreased [C-11]raclopride binding in a dose-dependent manner. However, the plots of percentage change in dopamine concentration in striatal EFC against that in [C-11]raclopride binding indicated differentrelationships between the effects of direct dopamine enhancers (GBR12909 and methamphetamine) and indirect dopamine modulators (benztropine and ketanserine). These results suggested that the alternation of [C-11]raclopride binding in vivo as measured by PET was differently affected by different neuronal manipulations, and not simply by the synaptic concentration of dopamine. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:24:00