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Titolo:
Dopamine receptor-modulated [S-35]GTP gamma S binding in striatum of 6-hydroxydopamine-lesioned rats
Autore:
Geurts, M; Hermans, E; Cumps, J; Maloteaux, JM;
Indirizzi:
Univ Catholique Louvain, Pharmacol Lab, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Catholique Louvain, Dept Pharmaceut Sci, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 841, anno: 1999,
pagine: 135 - 142
SICI:
0006-8993(19990911)841:1-2<135:DR[GSB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENYLATE-CYCLASE ACTIVITY; GUANINE-NUCLEOTIDE-BINDING; G-PROTEINS; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; BRAIN MEMBRANES; SUPERSENSITIVITY; AGONISTS; LESIONS; STIMULATION;
Keywords:
[S-35]GTP gamma S; striatum; 6-hydroxydopamine; receptor-G protein coupling; supersensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hermans, E Univ Catholique Louvain, Pharmacol Lab, FARL 5410,Ave Hippocrate 54, B-1200 Brussels, Belgium Univ Catholique Louvain FARL 5410,Ave Hippocrate 54 Brussels Belgium B-1200
Citazione:
M. Geurts et al., "Dopamine receptor-modulated [S-35]GTP gamma S binding in striatum of 6-hydroxydopamine-lesioned rats", BRAIN RES, 841(1-2), 1999, pp. 135-142

Abstract

The role of dopamine receptor-G protein coupling in the development of striatal dopamine receptor supersensitivity was studied in rats with a 6-hydroxydopamine (6-OHDA)-induced unilateral lesion of the nigrostriatal pathway. This coupling was assessed by the measurement of dopamine agonist-induced guanosine 5'-O-(gamma[S-35]thio)triphosphate ([S-35]GTP gamma S) binding instriatal membranes, at different periods of time (1-5 weeks) following themicroinjection of the neurotoxin. From the first to the fifth week following the lesion, basal and dopamine-stimulated [S-35]GTP gamma S-specific binding were found to be enhanced in the denervated striata as compared to their control counterpart. D-2 dopamine receptors were clearly demonstrated tobe involved in this supersensitivity, as assessed by measuring N-propylnorapomorphine (NPA)-, quinpirole- and bromocriptine-induced [S-35]GTP gamma S-specific binding. The involvement of D-1 dopamine receptors was indirectlystudied by the combination of dopamine with a saturating concentration of the selective and potent D-2 antagonist domperidone. In these conditions, the remaining response to dopamine was also found to be significantly increased following the lesion. These results are consistent with the hypothesis that, in addition to D-2 dopamine receptor upregulation, modulation of dopamine receptor-G protein interaction is involved in the hypersensitivity accompanying striatal dopamine depletion. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 12/07/20 alle ore 03:04:02