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Titolo:
Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
Autore:
Watanobe, H; Suda, T; Wikberg, JES; Schioth, HB;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Internal Med 3, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan Uppsala Univ, Dept Pharmaceut Pharmacol, BMC, SE-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75124 acol, BMC, SE-75124 Uppsala, Sweden Melacure Therapeut, Uppsala, Sweden Melacure Therapeut Uppsala SwedenMelacure Therapeut, Uppsala, Sweden
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 263, anno: 1999,
pagine: 162 - 165
SICI:
0006-291X(19990916)263:1<162:ETPLOC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL FEMALE MICE; OBESE GENE; PUBERTY; ONSET; TESTOSTERONE; SECRETION; STERILITY; CHILDREN; SIGNAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Watanobe, H Hirosaki Univ, Sch Med, Dept Internal Med 3, 5 Zaifu Cho, Hirosaki, Aomori0368216, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368216 Japan
Citazione:
H. Watanobe et al., "Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats", BIOC BIOP R, 263(1), 1999, pp. 162-165

Abstract

Increasing evidence suggests-that leptin, an adipocyte-derived hormone, may positively regulate the reproductive axis, and serve as a critical metabolic signal linking nutrition and the reproductive function. However, along this line there remains an as-of-yet unresolved important issue whether physiological levels of circulating leptin exert a stimulatory effect on the reproductive axis. It is also unknown whether hyperleptinemia affects the reproductive function. In this study, we attempted to examine these unexplored issues, employing as an indicator the estradiol/progesterone-induced luteinizing hormone (LH) and prolactin (PRL) surges in ovariectomized female rats. Experiments were performed on normally fed, 3-day starved, 3-day starved + murine leptin (100 mu g/kg/day), and normally fed + murine leptin (300 mu g/kg/day) groups. Leptin was administered utilizing osmotic minipumps during 3 days immediately before experimentation. From 11:00 to 18:00 h, blood was collected every 30 min to measure LH and PRL. The 3-day starvation completely abolished both LH and PRL surges, but 3-day starved + leptin (100 mu g/kg/day) group, whose plasma leptin levels (3.7 +/- 0.4 ng/ml) were similar to those in normally fed group (3.4 +/- 0.5 ng/ml), showed a significant recovery of the hormonal surges. On the other hand, the magnitudes of LHand PRL surges in normally fed + leptin (300 mu g/kg/day) group, whose leptin levels were 10.8 +/- 1.5 ng/ml, were statistically the same as those-innormally fed group. These results indicate for the first time that physiological concentrations of circulating leptin exert a stimulatory effect on the steroid-induced LH and PRL surges in the rat. It was also suggested thatmild hyperleptinemia of 3 days' duration may not significantly affect the hormonal surges, (C) 1999 Academic Press.

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Documento generato il 09/07/20 alle ore 18:04:37