Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Functions of cell surface heparan sulfate proteoglycans
Autore:
Bernfield, M; Gotte, M; Park, PW; Reizes, O; Fitzgerald, ML; Lincecum, J; Zako, M;
Indirizzi:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Dev & Newborn Biol, Boston, MA 02115 USA
Titolo Testata:
ANNUAL REVIEW OF BIOCHEMISTRY
, volume: 68, anno: 1999,
pagine: 729 - 777
SICI:
0066-4154(1999)68:<729:FOCSHS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; MAMMARY EPITHELIAL-CELLS; PROTEIN-KINASE-C; RECEPTOR-RELATED PROTEIN; DENSITY-LIPOPROTEIN-RECEPTOR; N-DEACETYLASE/N-SULFOTRANSFERASE; INTEGRAL MEMBRANE PROTEOGLYCAN; SYNDECAN CYTOPLASMIC DOMAINS; FOCAL ADHESION FORMATION; DORSAL-VENTRAL POLARITY;
Keywords:
glypicans; syndecans; extracellular matrix; growth factors; cell adhesion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
282
Recensione:
Indirizzi per estratti:
Indirizzo: Bernfield, M Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Biol, Boston, MA 02115 USA
Citazione:
M. Bernfield et al., "Functions of cell surface heparan sulfate proteoglycans", ANN R BIOCH, 68, 1999, pp. 729-777

Abstract

The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide-linked glypicans, bind these ligands and enhance formation of their receptor-signaling complexes. These heparan sulfate proteoglycans also immobilize and regulate the turnover of ligands that act at the cell surface. The extracellular domains of these proteoglycans can beshed from the cell surface, generating soluble heparan sulfate proteoglycans that can inhibit interactions at the cell surface. Recent analyses of genetic defects in Drosophila melanogaster, mice, and humans confirm most of these activities in vivo and identify additional processes that involve cell surface heparan sulfate proteoglycans. This chapter focuses on the mechanisms underlying these activities and on the cellular functions that they regulate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/05/20 alle ore 20:47:23