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Titolo:
Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes
Autore:
McIntosh, JM; Santos, AD; Olivera, BM;
Indirizzi:
Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Biol, Salt Lake City, UT 84112 USA Univ Utah, Dept Psychiat, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 chiat, Salt Lake City, UT 84112 USA Univ Philippines, Inst Chem, Quezon 1101, Philippines Univ Philippines Quezon Philippines 1101 Chem, Quezon 1101, Philippines
Titolo Testata:
ANNUAL REVIEW OF BIOCHEMISTRY
, volume: 68, anno: 1999,
pagine: 59 - 88
SICI:
0066-4154(1999)68:<59:CPTTSN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-CONOTOXIN GI; 3-DIMENSIONAL SOLUTION STRUCTURE; MUSCLE SODIUM-CHANNELS; DISTANCE GEOMETRY CALCULATIONS; RAT STRIATAL SYNAPTOSOMES; 1.1 ANGSTROM RESOLUTION; GATED ION-CHANNEL; CONANTOKIN-G; CRYSTAL-STRUCTURE; MARINE SNAIL;
Keywords:
conotoxin; antagonist; cone snail; ligand-gated ion channels;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: McIntosh, JM Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA Univ UtahSalt Lake City UT USA 84112 ake City, UT 84112 USA
Citazione:
J.M. McIntosh et al., "Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes", ANN R BIOCH, 68, 1999, pp. 59-88

Abstract

The venoms of predatory cone snails represent a rich combinatorial-like library of evolutionarily selected, neuropharmacologically active peptides. Amajor fraction of the venom components are conotoxins-small, disulfide-rich peptides that potently and specifically target components of the neuromuscular system, particularly ligand- and voltage-gated ion channels. This review focuses on Conus peptides, which act at nicotinic acetylcholine receptors. These nicotinic antagonist peptides from Conus are broadly divided intotwo groups: those that act at the neuromuscular junction and those that act at subtypes of neuronal nicotinic acetylcholine receptors. The latter include peptides specific for the alpha 7, alpha 3 beta 2, and alpha 3 beta 4 nicotinic receptor subtypes. The degree of specificity exhibited by these peptides is remarkable, particularly given their relatively small size. As agroup the nicotinic acetylcholine receptor-targeted Conus peptides represent an increasingly well-defined set of tools for probing the structure, function, and physiological role of nicotinic acetylcholine receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:45:44