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Titolo:
Immune responses against Plasmodium falciparum asexual blood-stage antigens and disease susceptibility in Gabonese and Cameroonian children
Autore:
Migot-Nabias, F; Luty, AJF; Ringwald, P; Vaillant, M; Dubois, B; Renaut, A; Mayombo, J; Minh, TN; Fievet, N; Mbessi, JR; Millet, P; Deloron, P;
Indirizzi:
Inst Francais Rech Sci Dev Cooperat Org Coordinat, Lab Rech Paludisme Lab Associe Francophone 302, Yaounde, Cameroon Inst Francais Rech Sci Dev Cooperat Org Coordinat Yaounde Cameroon roon Hop St Andre, Pouma, Cameroon Hop St Andre Pouma CameroonHop St Andre, Pouma, Cameroon CHU Bichat, Inst Med & Epidemiol Africaines, INSERM, U13, Paris, France CHU Bichat Paris France pidemiol Africaines, INSERM, U13, Paris, France
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 3, volume: 61, anno: 1999,
pagine: 488 - 494
SICI:
0002-9637(199909)61:3<488:IRAPFA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE SURFACE-ANTIGEN; NEW-GUINEAN CHILDREN; LYMPHOCYTE-RESPONSES; CELLULAR-RESPONSE; CLINICAL MALARIA; RHOPTRY ANTIGEN; PF155 RESA; ASSOCIATION; ANTIBODIES; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Migot-Nabias, F Ctr Int Rech Med Franceville, BP 769, Franceville, Gabon Ctr Int Rech Med Franceville BP 769 Franceville Gabon on
Citazione:
F. Migot-Nabias et al., "Immune responses against Plasmodium falciparum asexual blood-stage antigens and disease susceptibility in Gabonese and Cameroonian children", AM J TROP M, 61(3), 1999, pp. 488-494

Abstract

The frequency and level of cellular and humoral responses to seven synthetic peptides from asexual blood stages of Plasmodium falciparum were measured in two cohorts of children living in areas highly endemic for malaria in Gabon and Cameroon. A prospective longitudinal study was conducted for one year in these sites to examine the relationship between specific in vitro immune responses and susceptibility to clinical malaria. Clinical protectionwas related to high proliferative responses (merozoite surface antigen-1 [MSA-1] and MSA-2 peptides) as well as to elevated antibody levels (schizontextract, MSA-2, and rhoptry-associated protein-1 [RAP-1] peptides) in the village of Dienga, Gabon. Higher response rates of interferon-gamma but lower response rates of tumor necrosis factor-alpha to four and six peptides, respectively were observed in Dienga than in Pouma that were independent ofthe older age of the Gabonese children. Age accounted only for the higher prevalence rate in Dienga of the antibody responders to the peptide from Pf155/ring-infected erythrocyte surface antigen (RESA). Our results support the inclusion of epitopes from MSA-1, MSA-2, RAP-1, and Pf155/RESA antigens in a subunit vaccine against malaria, but show that a longitudinal clinical, parasitologic, and immunologic study conducted according to identical criteria in two separate areas may lead to contrasting observations, demonstrating the geographic limitation of the interpretation of such results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 13:40:51