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Titolo:
Association of a variant of the angiotensinogen gene with pure type of hypertension in pregnancy in the Japanese: Implication of a racial difference and significance of an age factor
Autore:
Kobashi, G; Hata, A; Shido, K; Kato, EH; Yamada, H; Fujimoto, S; Kishi, R; Kondo, K;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Publ Hlth, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Univ Air, Chiba 260, Japan Univ Air Chiba Japan 260Univ Air, Chiba 260, Japan
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 86, anno: 1999,
pagine: 232 - 236
SICI:
0148-7299(19990917)86:3<232:AOAVOT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREECLAMPSIA; ALLELE;
Keywords:
preeclampsia; genetic factor; polymorphism; maternal age;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kobashi, G Hokkaido Univ, Sch Med, Dept Publ Hlth, N15 W7, Sapporo, Hokkaido 0608638,Japan Hokkaido Univ N15 W7 Sapporo Hokkaido Japan 0608638 08638,Japan
Citazione:
G. Kobashi et al., "Association of a variant of the angiotensinogen gene with pure type of hypertension in pregnancy in the Japanese: Implication of a racial difference and significance of an age factor", AM J MED G, 86(3), 1999, pp. 232-236

Abstract

The contribution of genetic factors to hypertension in pregnancy, including preeclampsia, has been well documented. The association with a common molecular variant of the angiotensinogen (AGT) gene, in which methionine (M235) is substituted for threonine (T235) at residue 235, has been reported in both Caucasians and Japanese, In the present study, we examined 115 cases of pure type of hypertension in pregnancy (PHP) and 381 normal pregnant controls in order to look for subgroups in which the AGT gene is the major factor in the PHP pathogenesis. By classification of PHP cases according to theclinical diagnosis, gravidity, and maternal age, we found significantly higher frequencies of T235 in both all PHP patients and preeclampsia/eclampsia patients than in normal controls. These results are discordant with thosereported for Caucasian subjects where only a group of preeclamptic primigravidae was associated with the AGT variant, possibly indicating the existence of a racial difference. We also found that the variant frequency was significantly higher in the PHP subgroup with maternal age of 20-34 years (0.93) than in a subgroup of multigravid PHP patients age 35 years or older (0.77, P < 0.05) or in normal controls of age 20-34 years (0.76, P < 0.001). The result indicates that the AGT variant plays a significant role in hypertension in the age group 20-34 years. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:13:12