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Titolo:
Prolonged fenoldopam infusions in patients with mild to moderate hypertension - Pharmacodynamic and pharmacokinetic effects
Autore:
Taylor, AA; Shepherd, AM; Polvino, W; Mangoo-Karim, R; Ballard, K; Sunthornyothin, S; Luther, RR; Pool, JL;
Indirizzi:
Baylor Coll Med, Ctr Expt Therapeut, Dept Med, Sect Hypertens & Clin Pharmacol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 lin Pharmacol, Houston, TX 77030 USA Univ Texas, Hlth Sci Ctr, Div Clin Pharmacol, San Antonio, TX USA Univ Texas San Antonio TX USA r, Div Clin Pharmacol, San Antonio, TX USA IBRD Ctr Clin Res, Dept Pharmacol, Neptune, NJ USA IBRD Ctr Clin Res Neptune NJ USA in Res, Dept Pharmacol, Neptune, NJ USA IBRD Ctr Clin Res, Dept Med, Neptune, NJ USA IBRD Ctr Clin Res Neptune NJUSA Ctr Clin Res, Dept Med, Neptune, NJ USA Neurex Corp Inc, Menlo Park, CA USA Neurex Corp Inc Menlo Park CA USANeurex Corp Inc, Menlo Park, CA USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 9, volume: 12, anno: 1999,
parte:, 1
pagine: 906 - 914
SICI:
0895-7061(199909)12:9<906:PFIIPW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SEVERE SYSTEMIC HYPERTENSION; BLOOD-PRESSURE REDUCTION; INTRAVENOUS FENOLDOPAM; SODIUM-NITROPRUSSIDE; HEART-FAILURE; HUMAN-PLASMA; AGONIST; EMERGENCIES; MESYLATE;
Keywords:
hypertension; fenoldopam; pharmacokinetics; pharmacodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, AA Baylor Coll Med, Ctr Expt Therapeut, Dept Med, Sect Hypertens &Clin Pharmacol, Room 802E,1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med Room 802E,1 Baylor Plaza Houston TX USA 77030 A
Citazione:
A.A. Taylor et al., "Prolonged fenoldopam infusions in patients with mild to moderate hypertension - Pharmacodynamic and pharmacokinetic effects", AM J HYPERT, 12(9), 1999, pp. 906-914

Abstract

Thirty-three patients with mild-to-moderate essential hypertension received either placebo or fenoldopam, a selective dopamine-1 agonist, by intravenous infusion at a fixed infusion rate ranging from 0.1 to 0.8 mu g/kg/min for 48 h during a double-blind, placebo-controlled, randomized inpatient clinical trial. Blood pressure and heart rate were measured every 15 min for 24 h before, during, and 24 h after the 48-h drug infusion. Plasma concentrations of racemic fenoldopam were measured at frequent intervals during and for 24 h after fenoldopam infusion. In the 26 patients who received fenoldopam, there were dose-dependent reductions in systolic and diastolic blood pressure, which usually reached a nadir within 2 h of beginning infusion and were significant even at the lowest dose studied (-9 and -9 mm Hg for systolic and diastolic blood pressure, respectively, at 24 h far the dose of 0.04 mu g/kg/min, P < .05). There were associated increases in heart rate that were greater in the first than inthe last 24 h of drug infusion. Compared to the average 24-h control bloodpressure, maximum mean reductions in systolic and diastolic blood pressures of 33 and 21 mm Hg, respectively, were noted in patients receiving fenoldopam at 0.8 mu g/kg/min and occurred 4 and 1 h, respectively, after beginning infusion. Tolerance to the blood pressure lowering effects of the drug developed slowly during the 48 h of drug infusion; the half-life for this effect was 60 h. No serious adverse clinical effects were noted in any patient. These results demonstrate that fenoldopam is effective in reducing blood pressure of patients with mild-to-moderate hypertension at doses as low as 0.04 mu g/kg/min, is well tolerated at doses up to 0.8 mu g/kg/min, maintains most of its antihypertensive efficacy throughout 48 h of continuous, constant rate infusion, and produces neither prolonged pharmacodynamic effects nor rebound hypertension when discontinued. The pharmacodynamic effects of the drug are best predicted by pharmacokinetics of racemic and R-fenoldopam. Am J Hypertens 1999;12:906-914 (C) 1999 American Journal of Hypertension,Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:57:16