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Titolo:
'Multiple chemical sensitivity', the relevance of toxic, neurobiological and psychic effect mechanisms
Autore:
Kiesswetter, E;
Indirizzi:
Univ Dortmund, Inst Occupat Physiol, D-44221 Dortmund, Germany Univ Dortmund Dortmund Germany D-44221 hysiol, D-44221 Dortmund, Germany
Titolo Testata:
ZENTRALBLATT FUR HYGIENE UND UMWELTMEDIZIN
fascicolo: 2-4, volume: 202, anno: 1999,
pagine: 191 - 205
SICI:
0934-8859(199908)202:2-4<191:'CSTRO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; ODOR INTOLERANCE; BEHAVIORAL SENSITIZATION; ORGANIC-SOLVENTS; YOUNG-ADULTS; EXPOSURE; SYMPTOMS; MODEL; AMPHETAMINE; TOLUENE;
Keywords:
multiple chemical sensitivity; odour intolerance; dose-response relationship; organic solvents; toluene; olfactory-limbic sensitization; environmental stressors; odour; trait anxiety; psychological vulnerability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Kiesswetter, E Univ Dortmund, Inst Arbeitsphysiol, Ardeystr 67, D-44139 Dortmund, Germany Univ Dortmund Ardeystr 67 Dortmund Germany D-44139 Germany
Citazione:
E. Kiesswetter, "'Multiple chemical sensitivity', the relevance of toxic, neurobiological and psychic effect mechanisms", ZBL HYG UMW, 202(2-4), 1999, pp. 191-205

Abstract

The review deals mainly with the key question of chemical causation of multiple chemical sensitivity (MCS). There are only few human studies with valid information on chemical exposure and in no study the chemical toxic causation hypothesis is supported. The animal model of olfactory-limbic/neural sensitization is of heuristic value to explain MCS phenomena and includes both chemical and non-chemical stressors. However, in animal studies seldom chemical substances and exposure levels were used which might be of relevance in the formation of MCS. The problem is demonstrated for toluene exposures in human and animal sensitization studies. In accordance with the sensitization hypotheses, human studies prove a generalized vulnerability to environmental stimuli in subjects with self-reported MCS. However, study designs do not allow to deduce whether the strong responsivity is a premorbid or comorbid phenomenon or is related to exposure. Alternative study approachesto evaluate dose-response relationships are proposed.

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Documento generato il 27/01/21 alle ore 00:38:19