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Titolo:
Immunolocalization and quantitation of transforming growth factor alpha inhydatidiform mole
Autore:
Molykutty, J; Schultz, G; Rajalekshmy, TN; Enose, S; Nair, MK; Balaram, P;
Indirizzi:
Reg Canc Ctr, Div Res, Trivandrum 695011, Kerala, India Reg Canc Ctr Trivandrum Kerala India 695011 vandrum 695011, Kerala, India Inst Wound Res, Gainesville, FL USA Inst Wound Res Gainesville FL USAInst Wound Res, Gainesville, FL USA Med Coll Hosp, Trivandrum, Kerala, India Med Coll Hosp Trivandrum Kerala India ll Hosp, Trivandrum, Kerala, India
Titolo Testata:
TUMORI
fascicolo: 3, volume: 85, anno: 1999,
pagine: 183 - 187
SICI:
0300-8916(199905/06)85:3<183:IAQOTG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR RECEPTOR; HUMAN TROPHOBLAST; MESSENGER-RNA; FACTOR-BETA; EXPRESSION; DECIDUA; CELLS; PROLIFERATION; EGF;
Keywords:
decidua; hydatidiform mole; transforming growth factor-alpha; trophoblasts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Balaram, P Reg Canc Ctr, Div Res, Trivandrum 695011, Kerala, India Reg Canc Ctr Trivandrum Kerala India 695011 011, Kerala, India
Citazione:
J. Molykutty et al., "Immunolocalization and quantitation of transforming growth factor alpha inhydatidiform mole", TUMORI, 85(3), 1999, pp. 183-187

Abstract

Complete hydatidiform mole (CHM), a condition related to abnormal gestation, occurs predominantly in the young reproductive age group and has a high prevalence rate in the Trivandrum region, occurring in 1.2% of deliveries. Transforming growth factor alpha (TGF-alpha) is an important growth regulatory molecule, the location and function of which at the human fetomaternal interface in CHM remains to be determined, The present study examined the presence of TGF-alpha in the normal and complete molar placenta and decidua throughout gestation, A total of 149 complete molar placental tissue samples and 96 normal placental tissue samples were evaluated for TGF-alpha expression by immunohistochemistry and 50 each of CHM and normal placental tissue for TGF-alpha concentration by radioimmunoassay. The peptide was localized immunocytochemically with a monoclonal anti-TGF-alpha antibody on paraffin-embedded tissue using the avidin-biotin complex peroxidase technique withaminoethyl carbazole as the chromogen. In molar placenta, villous trophoblast cells (syncytiotrophoblasts and cytotrophoblasts) showed intense cytoplasmic staining at all gestational ages compared to normal placenta of the same gestational age. The tissue concentration of TGF-alpha was highly overexpressed in the molar placenta (10-1000 fold) compared to that in the normal placenta. The results indicate that TGF-alpha is present in trophoblasts throughout human gestation and may provide additional growth advantage to maintenance of the hyperproliferative condition in trophoblastic tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:19:59