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Titolo:
Localization of transforming growth factors beta 1 and beta 2 and epidermal growth factor in IgA nephropathy
Autore:
Taniguchi, Y; Yorioka, N; Masaki, T; Asakimori, Y; Yamashita, K; Yamakido, M;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Internal Med 2, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
fascicolo: 4, volume: 33, anno: 1999,
pagine: 243 - 247
SICI:
0036-5599(199908)33:4<243:LOTGFB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESANGIAL CELL-GROWTH; RENAL-DISEASE; HUMAN KIDNEY; EXPRESSION; RAT; GLOMERULONEPHRITIS; FIBROSIS; RECEPTOR; NECROSIS; ALPHA;
Keywords:
epidermal growth factor; IgA nephropathy; transforming growth factor-beta 1; transforming growth factor-beta 2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Yorioka, N Hiroshima Univ, Sch Med, Dept Internal Med 2, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 551, Japan
Citazione:
Y. Taniguchi et al., "Localization of transforming growth factors beta 1 and beta 2 and epidermal growth factor in IgA nephropathy", SC J UROL N, 33(4), 1999, pp. 243-247

Abstract

Objective: The localization of transforming growth factor (TGF)-beta 1, TGF-beta 2 and epidermal growth factor (EGF) was investigated in IgA nephropathy, and was compared with the severity of histological damage (including tubulointerstitial lesions). Materials and methods: The enzyme antibody method was used to stain paraffin-embedded sections of renal tissue from 42 patients with IgA nephropathy (19 males and 23 females). Results: There was a significant correlation between glomerular positivity for TGF-PI and TGF-beta 2 and the severity of histological damage. There was also a significant correlation between positivity for TGF-beta 1 and TGF-beta 2 in the tubularepithelium and tubulointerstitial lesions. In contrast, there was no relationship between glomerular positivity for EGF and histological damage, although there was a significant correlation between positivity for EGF in the tubular epithelium and tubulointerstitial lesions. Conclusions: These findings suggest that TGF-beta 1 and TGF-beta 2 may be important in the progression of IgA nephropathy. and that the distribution of EGF may also be a useful marker for the progression of renal damage, including tubulointerstitiallesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:54:32