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Titolo:
Development of velocity profiles and retrograde flow in the porcine abdominal aorta under different haemodynamic conditions
Autore:
Pedersen, EM; Kim, WY; Staalsen, NH; Hasenkam, JM; Nygaard, H; Paulsen, PK;
Indirizzi:
Aarhus Univ Hosp, Dept Cardiothorac & Vasc Surg, Skejby Sygehus, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N jby Sygehus, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp, Inst Expt Clin Res, Skejby Sygehus, DK-8200 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8200 Sygehus, DK-8200 Aarhus, Denmark Coll Engn, Aarhus, Denmark Coll Engn Aarhus DenmarkColl Engn, Aarhus, Denmark
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 4, volume: 33, anno: 1999,
pagine: 206 - 214
SICI:
1401-7431(1999)33:4<206:DOVPAR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
WALL SHEAR-STRESS; PULSED DOPPLER ULTRASOUND; HUMAN CORONARY-ARTERIES; IN-VIVO; ATHEROSCLEROTIC LESIONS; PULSATILE FLOW; PATTERNS; MODEL; EXERCISE;
Keywords:
abdominal aorta; blood velocity fields; Doppler ultrasound; exercise; flow reversal; haemodynamics; pigs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, EM Aarhus Univ Hosp, Dept Cardiothorac & Vasc Surg, Skejby Sygehus, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N DK-8200 Aarhus N, Denmark
Citazione:
E.M. Pedersen et al., "Development of velocity profiles and retrograde flow in the porcine abdominal aorta under different haemodynamic conditions", SC CARDIOVA, 33(4), 1999, pp. 206-214

Abstract

Low and/or oscillating wall shear stresses are related to the development of atherosclerosis and this oscillation is influenced by changes in basic haemodynamics (exercise). The objective of this study was to provide in vivodata on the development of velocity profiles and oscillating blood velocities in the abdominal aorta under varying haemodynamic conditions. Six anaesthetized, 90-kg pigs were used in the study. Abdominal aortic velocity profiles across the anterior-posterior diameter were acquired at different axial positions using 10 MHz pulsed Doppler ultrasound. Measurements were obtained under normal conditions and during cardiac pacing up to 170 beats/min. Velocity profiles were obtained during heart rates ranging between 58 and 169 beats/min, and during flow rates ranging between 0.57 and 2.89 l/min. Main outcome measures included minimum velocities, frequency index, shape of velocity profiles (velocity distribution index), Reynolds' numbers, and Womersley's frequency parameter. Velocity profiles were blunted, with lowest velocities at the distal posterior vessel wall. Multiple regression analysisshowed the development of velocity profiles to be inversely correlated with the pulsatility index, Womersley's frequency parameter and the mean Reynolds' number (r = 0.89, p < 0.0005). Minimum velocities were negatively correlated with the PI, Womersley's frequency parameter and positively with themean Reynolds' number (r = 0.94, p < 10(-8)). Retrograde velocities (and hence oscillating wall shear stresses) were present at mean Reynolds' number< 1000. The oscillation of blood velocities at the wall in the porcine abdominal aorta was highly dependent on general haemodynamics (i.e. flow, heart rate and vessel diameter as expressed in the Reynolds' numbers and Womersley's frequency parameters). The velocity profiles in the abdominal aorta were found to be far from parabolic. These findings have important implications for the understanding and future modelling of the complex haemodynamicsin the abdominal aorta and their relation to the development of atherosclerotic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:21:05