Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
Autore:
Hagan, JJ; Leslie, RA; Patel, S; Evans, ML; Wattam, TA; Holmes, S; Benham, CD; Taylor, SG; Routledge, C; Hemmati, P; Munton, RP; Ashmeade, TE; Shah, AS; Hatcher, JP; Hatcher, PD; Jones, DNC; Smith, MI; Piper, DC; Hunter, AJ; Porter, RA; Upton, N;
Indirizzi:
SmithKline Beecham Pharmaceut, Dept Discovery Chem, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 19, volume: 96, anno: 1999,
pagine: 10911 - 10916
SICI:
0027-8424(19990914)96:19<10911:OAALCC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTORS; NEURONS; HYPOTHALAMUS; PEPTIDES; BEHAVIOR;
Keywords:
immunocytochemistry; hypothalamus; sleep; locomotor activity; grooming;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hagan, JJ SmithKline Beecham Pharmaceut, Dept Discovery Chem, New Frontiers Sci Pk,3rd Ave, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut New Frontiers Sci Pk,3rd Ave Harlow Essex England CM19 5AW
Citazione:
J.J. Hagan et al., "Orexin A activates locus coeruleus cell firing and increases arousal in the rat", P NAS US, 96(19), 1999, pp. 10911-10916

Abstract

The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest thatorexin A plays an Important role in orchestrating the sleep-wake cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:28:16