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Titolo:
Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats
Autore:
Bakshi, VP; Geyer, MA;
Indirizzi:
Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA Univ Wisconsin Madison WI USA 53719 Dept Psychiat, Madison, WI 53719 USA Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 67, anno: 1999,
pagine: 385 - 392
SICI:
0031-9384(199909)67:3<385:OOIRDI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; EXCITOTOXIC HIPPOCAMPAL DAMAGE; PHENCYCLIDINE-INDUCED DEFICITS; PREPULSE INHIBITION; SOCIAL-ISOLATION; ANIMAL-MODEL; SCHIZOPHRENIC-PATIENTS; BEHAVIORAL-RESPONSES; REFLEX MODIFICATION;
Keywords:
schizophrenia; startle; prepulse inhibition; social isolation; locomotor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Geyer, MA Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA Univ Wisconsin Madison WI USA 53719 hiat, Madison, WI 53719 USA
Citazione:
V.P. Bakshi e M.A. Geyer, "Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats", PHYSL BEHAV, 67(3), 1999, pp. 385-392

Abstract

Presentation of a weak stimulus immediately before a startling stimulus decreases the magnitude of the resultant startle response. This phenomenon, termed prepulse inhibition (PPI), provides an operational measure of sensorimotor gating, and is deficient in schizophrenia patients. Clinically observed PPI deficits can be modeled in rodents by housing rats individually fromweaning until adulthood. The developmental time course of isolation rearing-induced PPI deficits, however, is unknown. The present studies characterized the ontogeny of isolation-induced PPI deficits and hyperactivity. Separate groups of Sprague-Dawley and Lister hooded rats were either singly housed (ISO) or socially housed (SOC, groups of two to three per cage) upon weaning and then maintained in these housing conditions for different periods of time until assessment of PPI and locomotor activity; animals were testedat time points that roughly corresponded to before puberty (2 weeks postweaning), during puberty (4 weeks postweaning), or after puberty (6-7 weeks post weaning). PPI deficits were seen in Sprague-Dawley ISO rats at either the 4- or 6-, but not the 2-week time points. In contrast, hyperactivity wasnoted in these animals starting at the 2-week time point. Lister rats showed the same general pattern of ISO-induced effects, with ISO-induced hyperactivity (observed 4 weeks postweaning) preceding ISO-induced PPI deficits (observed 7 weeks postweaning). Therefore, ISO produces dissociable effects on PPI and locomotor activity, with PPI deficits emerging only during or after puberty. ISO might thus provide a useful noninvasive tool with which tostudy the neural substrates of delayed-onset sensorimotor gating abnormalities. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:09:46