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Titolo:
Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
Autore:
Haynes, AC; Jackson, B; Overend, P; Buckingham, RE; Wilson, S; Tadayyon, M; Arch, JRS;
Indirizzi:
SmithKline Beecham Pharmaceut, Vasc Biol, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England SmithKline Beecham Pharmaceut, Stat Sci, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England SmithKline Beecham Pharmaceut, Funct Gene Anal, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England
Titolo Testata:
PEPTIDES
fascicolo: 9, volume: 20, anno: 1999,
pagine: 1099 - 1105
SICI:
0196-9781(199909)20:9<1099:EOSACI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANIN-CONCENTRATING HORMONE; LATERAL HYPOTHALAMIC AREA; PEPTIDE YY PYY; NEUROPEPTIDE-Y; BODY-WEIGHT; FOOD-INTAKE; BEHAVIOR; INCREASES; OBESITY; ANTAGONIZES;
Keywords:
orexins; i.c.v. administration; feeding; light-dark cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Haynes, AC SmithKline Beecham Pharmaceut, Vasc Biol, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD nd
Citazione:
A.C. Haynes et al., "Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat", PEPTIDES, 20(9), 1999, pp. 1099-1105

Abstract

Two novel hypothalamic neuropeptides, orexin-A and -B, are suggested to regulate feeding. A single intracerebroventricular injection of orexin-A (23.4 nmol), administered 3 h into the light phase, increased feeding in satiated rats and prolonged feeding in fasted rats; it also increased feeding when given 6 h into, but not at the start of, the dark phase. An 8-day intracerebroventricular infusion with orexin-A (18 nmol/day) increased daytime feeding on days 2 and 8, but nocturnal feeding was reduced and there was no change in 24 h intake. Orexin-B had no effects. These results demonstrate a circadian variation in feeding responses to orexin-A. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:13:13