Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Factors affecting survival rates for acute vertebrobasilar artery occlusions treated with intra-arterial thrombolytic therapy: A meta-analytical approach
Autore:
Levy, EI; Firlik, AD; Wisniewski, S; Rubin, G; Jungreis, CA; Wechsler, LR; Yonas, H;
Indirizzi:
Univ Pittsburgh, Med Ctr, Dept Neurosurg, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 urosurg, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Epidemiol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 idemiol, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Radiol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Radiol, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Neurol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Neurol, Pittsburgh, PA 15213 USA
Titolo Testata:
NEUROSURGERY
fascicolo: 3, volume: 45, anno: 1999,
pagine: 539 - 545
SICI:
0148-396X(199909)45:3<539:FASRFA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIAGNOSIS;
Keywords:
basilar artery; stroke; thrombolysis; urokinase; vertebrobasilar artery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yonas, H Univ Pittsburgh, Med Ctr, Dept Neurosurg, Suite B-400,200 LothropSt, Pittsburgh, PA 15213 USA Univ Pittsburgh Suite B-400,200 Lothrop St Pittsburgh PA USA 15213
Citazione:
E.I. Levy et al., "Factors affecting survival rates for acute vertebrobasilar artery occlusions treated with intra-arterial thrombolytic therapy: A meta-analytical approach", NEUROSURGER, 45(3), 1999, pp. 539-545

Abstract

OBJECTIVE: To determine whether recanalization, coma at presentation, or clot location in the basilar artery influences the relative mortality risk after intra-arterial thrombolytic therapy for acute vertebrobasilar artery occlusions. METHODS: Studies were identified using the MEDLINE database for January 1987 to November 1997. Series were included if they involved 10 or more patients with basilar or vertebrobasilar artery occlusions, used urokinase and/or recombinant tissue plasminogen activator, and were written in English. A fixed-effect meta-analysis approach was used to estimate the risk of death with the aforementioned risk factors. Each study was weighted according to sample size. Relative risks were calculated with 95% confidence intervals. RESULTS: As calculated from peer-reviewed published data, the relative mortality risk for patients for whom recanalization was attempted but not achieved was 2.34 (95% confidence interval, 1.48-3.71; n = 126). Coma at presentation was associated with a relative mortality risk of 1.95 (95% confidence interval, 1.26-2.99; n = 145). Clot locations in the distal one-third of the basilar artery were shown to favor survival, compared with clots located in the proximal and/or middle portions of the basilar artery (relative risk, 0.52; 95% confidence interval, 0.31-0.86; n = 126). CONCLUSION: The combined data suggest that coma at presentation has an independent and adverse effect on survival rates. Complete recanalization, distal clot location, and responsiveness at the time of presentation are statistically significant factors for increased patient survival rates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 08:32:04