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Titolo:
Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis
Autore:
Tourbah, A; Stievenart, JL; Gout, O; Fontaine, B; Liblau, R; Lubetzki, C; Cabanis, EA; Lyon-Caen, O;
Indirizzi:
Univ Paris 06, Hop Salpetriere, Fed Neurol, F-75651 Paris 13, France Univ Paris 06 Paris France 13 iere, Fed Neurol, F-75651 Paris 13, France Univ Paris 06, Hop Salpetriere, Fac Med Pitie Salpetriere, F-75651 Paris, France Univ Paris 06 Paris France F-75651 ie Salpetriere, F-75651 Paris, France Hop La Pitie Salpetriere, Ctr Hosp Natl Opthalmol XV XX, CJF Pathol Myeline 97 11, Serv Neuroradiol, Paris, France Hop La Pitie Salpetriere Paris France , Serv Neuroradiol, Paris, France Hop Beaujon, Serv Biophys & Med Cellulaire, Clichy, France Hop Beaujon Clichy France Serv Biophys & Med Cellulaire, Clichy, France Hop La Pitie Salpetriere, Lab Immunol Cellulaire, Paris, France Hop La Pitie Salpetriere Paris France Immunol Cellulaire, Paris, France Fdn A Rothschild, Serv Neurol, Paris, France Fdn A Rothschild Paris France A Rothschild, Serv Neurol, Paris, France
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 53, anno: 1999,
pagine: 1091 - 1097
SICI:
0028-3878(19990922)53:5<1091:LPMRSI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; L-ASPARTIC ACID; DEMYELINATING LESIONS; MR SPECTROSCOPY; HUMAN-BRAIN; DISABILITY; PATHOLOGY; INCREASE; PLAQUES; INVIVO;
Keywords:
proton magnetic resonance spectroscopy; relapsing-remitting MS; secondary progressive MS; normal-appearing white matter; axonal damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tourbah, A Univ Paris 06, Hop Salpetriere, Fed Neurol, 47 Bld Hop, F-75651Paris 13, France Univ Paris 06 47 Bld Hop Paris France 13 5651 Paris 13, France
Citazione:
A. Tourbah et al., "Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis", NEUROLOGY, 53(5), 1999, pp. 1091-1097

Abstract

Objective: To determine the efficacy of MRS in discriminating between relapsing remitting (RR) and secondary progressive (SP) MS. Methods: MRS at long and short echo times was carried out in 104 patients with MS stratified for clinical course (RR or SP), and the results were compared with those of 15 control subjects. Normal-appearing white matter (NAWM) was studied in 55patients, and a high-T2-signal area on MRI in 49 others. Results: At long echo times, there was a highly significant decrease in the ratios N-acetyl-aspartate/creatine (NAA/Cr) and NAA/choline (Cho) in high-T2-signal areas and in the NAWM in patients with an SP course compared with control subjectsand patients with an RR course. There was a significant negative correlation between these ratios and clinical disability measured by Expanded Disability Status Scale score, which was independent of disease duration. Discriminant values between patients with RR and SP courses were found in the NAWM(NAA/Cr = 1.75 and NAA/Cho = 1.5), but not in high-T2-signal areas. At short echo times, there was a significant increase in the ratio myoinositol/Crin high-signal areas of patients with an SP course compared with control subjects, and the presence of abnormal resonances in the lesions and NAWM for free amino acids and lipids (in 30% and 8%, respectively) and GLX complex(glutamine, glutamate, gamma-aminobutyric acid; 16% and 20%, respectively). Conclusions: Studying normal-appearing white matter on MRI with MRS allows discrimination between relapsing remitting and secondary progressive patients. In the NAWM of patients with MS and an SP course, severe axonal loss/dysfunction is negatively correlated to clinical disability and independentof the duration of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:45:56