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Titolo:
Vulnerability of the nigrostriatal system as detected by transcranial ultrasound
Autore:
Berg, D; Becker, G; Zeiler, B; Tucha, O; Hofmann, E; Preier, M; Benz, P; Jost, W; Reiners, K; Lange, KW;
Indirizzi:
Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Neurol, D-97080 Wurzburg, Germany Univ Wurzburg, Div Neuroradiol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 radiol, D-97080 Wurzburg, Germany Univ Regensburg, Dept Neuropsychol, D-8400 Regensburg, Germany Univ Regensburg Regensburg Germany D-8400 ol, D-8400 Regensburg, Germany PET Zentrum, Mainz, Germany PET Zentrum Mainz GermanyPET Zentrum, Mainz, Germany Univ Mainz, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500Univ Mainz, D-6500 Mainz, Germany Deutsch Klin Diagnost, D-6200 Wiesbaden, Germany Deutsch Klin Diagnost Wiesbaden Germany D-6200 D-6200 Wiesbaden, Germany
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 53, anno: 1999,
pagine: 1026 - 1031
SICI:
0028-3878(19990922)53:5<1026:VOTNSA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; F-18 DOPA-PET; PARKINSONS-DISEASE; MAGNETIC-RESONANCE; SUBSTANTIA-NIGRA; IRON CONTENT; BRAIN; TIME; T2; HUNTINGTON;
Keywords:
nigrostriatal system; preclinical impairment; transcranial ultrasound; MRI; [F-18]-dopa PET; neuropsychological assessment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, G Univ Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080 y
Citazione:
D. Berg et al., "Vulnerability of the nigrostriatal system as detected by transcranial ultrasound", NEUROLOGY, 53(5), 1999, pp. 1026-1031

Abstract

Objective: To assess the incidence of a hyperechogenic substantia nigra (SN) by transcranial sonography (TCS) in healthy people and to evaluate whether an enlarged hyperechogenic SN area is associated with functional impairment of the nigrostriatal system. Background and Methods: Until now, preclinical impairment of the nigrostriatal system could be identified only by functional neuroimaging techniques such as PET in selected groups of patients. TCS is a new, noninvasive ultrasound technique that has demonstrated an increased echogenicity of the SN in patients with PD, whereas in most healthyindividuals, the SN is either barely detectable or undetectable by TCS. Results: Of 330 healthy volunteers, 8.6% exhibited an increased echogenicity of the SN. From these, 10 clinically healthy individuals with distinct unilateral or bilateral hyperechogenic signals in the SN region (SN area above 0.25 cm(2)) underwent comprehensive motor testing, neuropsychological assessment, MRI, and [F-18]-dopa PET examination. With regard to motor functions, these individuals did not differ from 10 age- and sex-matched controls with a low echogenic SN and an area of echogenic signals below 0.2 cm(2). Enlargement of hyperechogenic areas in the 10 healthy individuals was associated with a marked decrease in the accumulation of [F-18]-dopa in the caudatenucleus and putamen. Conclusions: Substantia nigra hyperechogenicity appears to indicate a functional impairment of the nigrostriatal system. Transcranial sonography may be a suitable method of identifying persons at risk ofnigrostriatal alterations, making possible the introduction of early neuroprotective therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:51:08