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Titolo:
Influence of lamotrigine on progression of early Huntington disease - A randomized clinical trial
Autore:
Kremer, B; Clark, CM; Almqvist, EW; Raymond, LA; Graf, P; Jacova, C; Mezei, M; Hardy, MA; Snow, B; Martin, W; Hayden, MR;
Indirizzi:
Univ British Columbia, Ctr Mol Med & Therapeut, Dept Psychiat, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ British Columbia, Dept Psychol, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ British Columbia, Div Neurol, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ Nijmegen, Dept Neurol, Nijmegen, Netherlands Univ Nijmegen NijmegenNetherlands , Dept Neurol, Nijmegen, Netherlands Auckland Hosp, Dept Neurol Neurophysiol, Auckland, New Zealand Auckland Hosp Auckland New Zealand Neurophysiol, Auckland, New Zealand Univ Alberta, Dept Med Neurol, Edmonton, AB, Canada Univ Alberta EdmontonAB Canada a, Dept Med Neurol, Edmonton, AB, Canada
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 53, anno: 1999,
pagine: 1000 - 1011
SICI:
0028-3878(19990922)53:5<1000:IOLOPO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; TRINUCLEOTIDE REPEAT LENGTH; NEUROPROTECTIVE STRATEGIES; GLUCOSE-UTILIZATION; FUNCTIONAL DECLINE; CORTICAL-NEURONS; QUINOLINIC ACID; RAT STRIATUM; CELL-DEATH; RILUZOLE;
Keywords:
Huntington disease; lamotrigine; drug trial; indices of progression; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hayden, MR Univ British Columbia, Ctr Mol Med & Therapeut, Dept Psychiat, Room 3026-950 W 28th Ave, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Room 3026-950 W 28th Ave Vancouver BC Canada V5Z 4H4
Citazione:
B. Kremer et al., "Influence of lamotrigine on progression of early Huntington disease - A randomized clinical trial", NEUROLOGY, 53(5), 1999, pp. 1000-1011

Abstract

Objective: To assess the efficacy of lamotrigine, a novel antiepileptic drug that inhibits glutamate release, to retard disease progression in Huntington disease (HD). Background: Excitatory amino acids may cause selective neuronal death in HD, and lamotrigine may inhibit glutamate release in vivo. Methods: A double-blinded, placebo-controlled study was conducted of 64 patients with motor signs of less than 5 years' duration who were randomly assigned to either placebo or lamotrigine and assessed at 0 (baseline), 12, 24, and 30 months. The primary response variable was total functional capacity (TFC) score. Secondary response variables included the quantified neurological examination and a set of cognitive and motor tests. Repeated fluorodeoxyglucose measurements of regional cerebral metabolism using PET also were included. Results: Fifty-five patients (28 on lamotrigine, 27 on placebo)completed the study. Neither the primary response variable nor any of the secondary response variables differed significantly between the treatment groups. Both the lamotrigine and the placebo group deteriorated significantly on the TFC, in the lamotrigine group by 1.89 and the placebo group by 2.11 points. No effect of CAG size on the rate of deterioration could be detected. Conclusions: There was no clear evidence that lamotrigine retarded theprogression of early Huntington disease over a period of 30 months. However, more patients on lamotrigine reported symptomatic improvement (53.6 versus 14.8%; p = 0.006), and a trend toward decreased chorea was evident in the treated group (p = 0.08). The study also identified various indices of disease progression, including motor tests and PET studies, that were sensitive to deterioration over time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:21:44