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Titolo:
A randomized trial of risperidone, placebo, and haloperidol for behavioralsymptoms of dementia
Autore:
De Deyn, PP; Rabheru, K; Rasmussen, A; Bocksberger, JP; Dautzenberg, PLJ; Eriksson, S; Lawlor, BA;
Indirizzi:
Univ Antwerp, Born Bunge Fdn, Gen Hosp Middelheim, Dept Neurol, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 Dept Neurol, B-2610 Wilrijk, Belgium Univ Antwerp, Born Bunge Fdn, Lab Neurochem & Behav, Wilrijk, Belgium UnivAntwerp Wilrijk Belgium n, Lab Neurochem & Behav, Wilrijk, Belgium Hosp Psychiat, London, ON, Canada Hosp Psychiat London ON CanadaHosp Psychiat, London, ON, Canada Frederiksberg Hosp, Psychiat Res Clin, Frederiksberg, Denmark Frederiksberg Hosp Frederiksberg Denmark s Clin, Frederiksberg, Denmark Univ Hosp Geneva, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland iv Hosp Geneva, Geneva, Switzerland Bosch Medictr, Hertogenbosch, Netherlands Bosch Medictr Hertogenbosch Netherlands ctr, Hertogenbosch, Netherlands Umea Univ, Dept Geriatr Med, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 iv, Dept Geriatr Med, S-90187 Umea, Sweden St James Hosp, Dept Psychiat, Jonathan Swift Clin, Dublin 8, Ireland St James Hosp Dublin Ireland 8 t, Jonathan Swift Clin, Dublin 8, Ireland
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 53, anno: 1999,
pagine: 946 - 955
SICI:
0028-3878(19990922)53:5<946:ARTORP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; SENILE DEMENTIA; RATING-SCALE; SCHIZOPHRENIA; METAANALYSIS; MULTICENTER; PREVALENCE; EFFICACY; BURDEN;
Keywords:
risperidone; aggression; behavioral symptoms; dementia; extrapyramidal symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: De Deyn, PP Univ Antwerp, Born Bunge Fdn, Gen Hosp Middelheim, Dept Neurol, Univ Plein1, B-2610 Wilrijk, Belgium Univ Antwerp Univ Plein 1 Wilrijk Belgium B-2610 ijk, Belgium
Citazione:
P.P. De Deyn et al., "A randomized trial of risperidone, placebo, and haloperidol for behavioralsymptoms of dementia", NEUROLOGY, 53(5), 1999, pp. 946-955

Abstract

Objective: To compare effects of risperidone with placebo (efficacy and tolerability) and haloperidol (tolerability) for treating demented patients with aggression and other behavioral symptoms. Methods: A 13-week double-blind study involving 344 patients with dementia randomly assigned to receive placebo or flexible doses (0.5 to 4 mg/d) of risperidone or haloperidol. Behavioral symptoms were assessed by the Behavior Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), the Cohen-Mansfield Agitation Inventory (CMAI), and the Clinical Global Impression (CGI) scale. Tolerability assessments included the Extrapyramidal Symptom Rating Scale, sedation levels, Functional Assessment Staging, Mini-Mental State Examination, and incidence of adverse events. Results: The mean dose at endpoint was 1.1 mg/d of risperidone and 1.2 mg/d of haloperidol. Although not significant, a higher percentage of patients receiving risperidone than those receiving placebo showed clinical improvement (greater than or equal to 30% reduction from baseline toendpoint in BEHAVE-AD total score) at endpoint and week 12. Reductions in the BEHAVE-AD total score were significantly greater with risperidone than with placebo at week 12. In a further analysis of aggression, the most dominant symptom in these patients, BEHAVE-AD and CMAI aggression cluster scores were significantly reduced compared with placebo at endpoint and week 12. CGI scores were also significantly reduced at endpoint and week 12. Severity of extrapyramidal symptoms with risperidone did not differ significantlyfrom that of placebo and was less than that of haloperidol. A post hoc analysis showed significantly greater reductions in the BEHAVE-AD aggressiveness score with risperidone than haloperidol at week 12. Conclusion: Low-doserisperidone (mean 1.1 mg/d) was well tolerated and associated with reductions in the severity and frequency of behavioral symptoms, particularly aggression, in elderly patients with dementia.

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Documento generato il 19/01/20 alle ore 20:35:00