Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Vigabatrin, a gabaergic antiepileptic drug, causes concentric visual fielddefects
Autore:
Kalviainen, R; Nousiainen, I; Mantyjarvi, M; Nikoskelainen, E; Partanen, J; Partanen, K; Riekkinen, P;
Indirizzi:
Kuopio Univ Hosp, Dept Neurol, Kuopio 70211, Finland Kuopio Univ Hosp Kuopio Finland 70211 Dept Neurol, Kuopio 70211, Finland Kuopio Univ Hosp, Dept Ophthalmol, Kuopio, Finland Kuopio Univ Hosp Kuopio Finland Hosp, Dept Ophthalmol, Kuopio, Finland Kuopio Univ Hosp, Dept Neurophysiol, Kuopio, Finland Kuopio Univ Hosp Kuopio Finland osp, Dept Neurophysiol, Kuopio, Finland Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland Kuopio Univ Hosp Kuopio Finland Univ Hosp, Dept Radiol, Kuopio, Finland Turku Univ Hosp, Dept Ophthalmol, Turku, Finland Turku Univ Hosp Turku Finland niv Hosp, Dept Ophthalmol, Turku, Finland Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 nen Inst, FIN-70211 Kuopio, Finland
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 53, anno: 1999,
pagine: 922 - 926
SICI:
0028-3878(19990922)53:5<922:VAGADC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-VINYL GABA; EVOKED-POTENTIALS; CARBAMAZEPINE; EPILEPSY; LESIONS; SYSTEM;
Keywords:
visual field defect; vigabatrin; antiepileptic drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kalviainen, R Kuopio Univ Hosp, Dept Neurol, POB 1777, Kuopio 70211, Finland Kuopio Univ Hosp POB 1777 Kuopio Finland 70211 211, Finland
Citazione:
R. Kalviainen et al., "Vigabatrin, a gabaergic antiepileptic drug, causes concentric visual fielddefects", NEUROLOGY, 53(5), 1999, pp. 922-926

Abstract

Objective: To determine whether there is a causal link between vigabatrin treatment and concentric visual field defects and to evaluate the prevalence of these visual field constrictions. Background: While the GABAergic antiepileptic drug (AED) vigabatrin was being clinically developed, only rare cases (less than 1:1000) of symptomatic visual field constriction and retinal disorders were reported. During 1997 to 1998, concentric visual field constrictions were described in case reports of mostly drug-resistant epilepsypatients receiving vigabatrin concurrently with other AEDs. Methods: Ophthalmologic tests including Goldmann perimetry were performed on 32 adult patients on long-term successful vigabatrin monotherapy (treatment duration 29to 119 months) and on 18 patients on carbamazepine monotherapy (treatment duration 32 to 108 months). Eighteen healthy adults served as controls. Results: None of the patients complained about vision problems when asked to participate into the study. Thirteen out of the 32 (40%) epilepsy patients treated with vigabatrin monotherapy had concentrically constricted visual fields (9% severely, 31% mildly constricted), whereas none of the carbamazepine monotherapy patients or normal controls presented with a visual field defect (chi-square test, p = 0.0001). The extents of the visual fields were significantly constricted in vigabatrin group as compared with the visual fields of the patients in carbamazepine group or healthy controls (analysis of variance, Scheffe F-test, significant at 99%). Conclusions: The use of vigabatrin seems to increase the risk of a unique and specific pattern of bilateral, mainly asymptomatic visual field constriction. This risk should be considered when using vigabatrin. Visual field testing should also be performed before treatment and during routine follow-up for patients on vigabatrin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:49:56