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Titolo:
Psychobiological aspects of posttraumatic stress disorder
Autore:
Ehlert, U; Wagner, D; Heinrichs, M; Heim, C;
Indirizzi:
Univ Trier, Forschungszentrum Psychobiol & Psychosomat, Trier, Germany Univ Trier Trier Germany ntrum Psychobiol & Psychosomat, Trier, Germany
Titolo Testata:
NERVENARZT
fascicolo: 9, volume: 70, anno: 1999,
pagine: 773 - 779
SICI:
0028-2804(199909)70:9<773:PAOPSD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
GER
Soggetto:
PITUITARY-ADRENAL-AXIS; DEXAMETHASONE SUPPRESSION TEST; COMBAT-RELATED STIMULI; GLUCOCORTICOID RECEPTOR; SYMPATHOADRENAL SYSTEM; CEREBROSPINAL-FLUID; DEPRESSION; PLASMA; TRAUMA; PTSD;
Keywords:
posttraumatic stress disorder; hypothalamic-pituitary-adrenocortical axis catecholamines; neuroimaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Ehlert, U Univ Zurich, Abt Klin Psychol, Zurichbergstr 43, CH-8044 Zurich,Switzerland Univ Zurich Zurichbergstr 43 Zurich Switzerland CH-8044 zerland
Citazione:
U. Ehlert et al., "Psychobiological aspects of posttraumatic stress disorder", NERVENARZT, 70(9), 1999, pp. 773-779

Abstract

The exposure to a traumatic event may result in posttraumatic stress disorder (PTSD), which is characterized by a complex symptomatology, clustered into three groups of symptoms, i.e. intrusive memories,avoidance behavior, and hyperarousal. Since PTSD is a stress reaction, alterations of stress-responses of neurobiological systems have been examined in patients suffering from PTSD. The investigation of biological parameters refers to the hypothalamic-pituitary-adrenal axis (HPA), studies of the noradrenergic and the endogenous opiate system as well as psychophysiological and neuroi-maging studies. Besides others, the observed biological dysregulations refer to hypocortisolism with an enhanced negative feedback of the HPA axis, enhanced noradrenergic activity, and neuroanatomical changes. To elucidate the specifity of this findings for PTSD,the dysregulations will be discussed with reference to findings in major depression and somatoform disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:18:13