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Titolo:
Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe
Autore:
Le Goff, X; Woollard, A; Simanis, V;
Indirizzi:
Swiss Inst Expt Canc Res, Cell Cycle Control Lab, CH-1066 Epalinges, Switzerland Swiss Inst Expt Canc Res Epalinges Switzerland CH-1066 nges, Switzerland Imperial Canc Res Fund, Cell Cycle Control Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England MRC, Mol Biol Lab, Div Cell Biol, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH Div Cell Biol, Cambridge CB2 2QH, England
Titolo Testata:
MOLECULAR AND GENERAL GENETICS
fascicolo: 1, volume: 262, anno: 1999,
pagine: 163 - 172
SICI:
0026-8925(199908)262:1<163:AOTCGP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DIVISION CYCLE; FISSION YEAST-CELL; PROTEIN-KINASE HOMOLOG; SEPTUM FORMATION; S-POMBE; MORPHOGENESIS CHECKPOINT; DNA-REPLICATION; BUDDING YEAST; ACTIN RING; F-ACTIN;
Keywords:
1,3-beta-D-glucan synthase; cell cycle; actin; cytokinesis; mitosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Simanis, V Swiss Inst Expt Canc Res, Cell Cycle Control Lab, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland Swiss Inst Expt Canc Res Chemin des Boveresses 155 Epalinges Switzerland CH-1066
Citazione:
X. Le Goff et al., "Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe", MOL G GENET, 262(1), 1999, pp. 163-172

Abstract

The fission yeast gene cps1, which encodes the catalytic subunit of beta-glucan synthase, was isolated in a screen for mutants that show an increase in ploidy at the restrictive temperature. cps1 mutants display defects in both polarity and septation at the permissive temperature, and become swollen and multinucleate at the restrictive temperature. Analysis of the interaction of cps1 with other mutations suggests the existence of a septation checkpoint, which requires the activity of the protein kinase wee1 for function.

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Documento generato il 08/04/20 alle ore 08:55:46