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Titolo:
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis
Autore:
Peruzzi, F; Prisco, M; Dews, M; Salomoni, P; Grassilli, E; Romano, G; Calabretta, B; Baserga, R;
Indirizzi:
Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 10, volume: 19, anno: 1999,
pagine: 7203 - 7215
SICI:
0270-7306(199910)19:10<7203:MSPOTI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-I RECEPTOR; DOMINANT-NEGATIVE MUTANT; PROTEIN-KINASE AKT; INDUCED CELL-DEATH; PHOSPHATIDYLINOSITOL 3'-KINASE; IGF-I; HEMATOPOIETIC-CELLS; BREAST-CANCER; INDUCED PHOSPHORYLATION; NUCLEAR TRANSLOCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Baserga, R Thomas Jefferson Univ, Kimmel Canc Ctr, 624 Bluemle Life Sci Bldg,233 S 10th St, Philadelphia, PA 19107 USA Thomas Jefferson Univ 624 Bluemle Life Sci Bldg,233 S 10th St Philadelphia PA USA 19107
Citazione:
F. Peruzzi et al., "Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis", MOL CELL B, 19(10), 1999, pp. 7203-7215

Abstract

The type 1 insulin-like growth factor receptor (IGF-1R), activated by its ligands, protects several cell types from a variety of apoptotic injuries. The main signaling pathway for IGF-1R-mediated protection from apoptosis has been previously elucidated and rests on the activation of phosphatidylinositol 3-kinase, Akt/protein kinase B, and the phosphorylation and inactivation of BAD, a member of the Bcl-2 family of proteins, In 32D cells (a murine hemopoietic cell line devoid of insulin receptor substrate 1 [IRS-1]), the IGF-1R activates alternative pathways for protection from apoptosis induced by withdrawal of interleukin-3. One of these pathways leads to the activation of mitogen-activated protein kinase, while a third pathway results inthe mitochondrial translocation of Raf and depends on the integrity of a group of serines in the C terminus of the receptor that are known to interact with 14.3.3 proteins. All three pathways, however, result in BAD phosphorylation. The presence of multiple antiapoptotic pathways may explain the remarkable efficacy of the IGF-1R in protecting cells from apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:37:14