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Titolo:
Drugs that induce neutropenia/agranulocytosis may target specific components of the stromal cell extracellular matrix
Autore:
Guest, I; Uetrecht, J;
Indirizzi:
Univ Toronto, Fac Pharm, Toronto, ON M5S 2S2, Canada Univ Toronto TorontoON Canada M5S 2S2 Pharm, Toronto, ON M5S 2S2, Canada Univ Toronto, Fac Med, Toronto, ON M5S 2S2, Canada Univ Toronto Toronto ON Canada M5S 2S2 c Med, Toronto, ON M5S 2S2, Canada
Titolo Testata:
MEDICAL HYPOTHESES
fascicolo: 2, volume: 53, anno: 1999,
pagine: 145 - 151
SICI:
0306-9877(199908)53:2<145:DTINMT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; BONE-MARROW STROMA; HEPARAN-SULFATE PROTEOGLYCANS; VASCULAR ENDOTHELIAL-CELLS; INDUCED AGRANULOCYTOSIS; BENZENE METABOLITES; ADHESION MOLECULES; STEM-CELLS; REACTIVE METABOLITES; MYELOID PROGENITORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Uetrecht, J Univ Toronto, Fac Pharm, 19 Russell St, Toronto, ON M5S 2S2, Canada Univ Toronto 19 Russell St Toronto ON Canada M5S 2S2 2, Canada
Citazione:
I. Guest e J. Uetrecht, "Drugs that induce neutropenia/agranulocytosis may target specific components of the stromal cell extracellular matrix", MED HYPOTH, 53(2), 1999, pp. 145-151

Abstract

The etiology of drug-induced agranulocytosis is poorly understood. Many drugs that induce neutropenia or agranulocytosis can be metabolized to reactive intermediates that covalently bind to macromolecules. Until now, the myeloid precursor cell or an earlier committed progenitor cell has been favoured as the target for toxicity, due to evidence in some cases of cytotoxic action or antibodies against neutrophils. in the bone marrow, where neutrophils mature, certain components of the stromal microenvironment, e.g. intracellular adhesion molecule 1, vascular cell adhesion molecule 1, CD11b/CD18,heparan sulfate proteoglycans, fibronectin and hemonectin are essential for normal myeloid maturation. This article proposes that drugs implicated inagranulocytosis, or more likely their reactive metabolites, interact with specific components of the extracellular matrix and interfere with the normal regulation of granulopoiesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:00:26