Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pre-eclampsia: a mistake of trophoblastic cells for tumour cells?
Autore:
Brown, DW;
Titolo Testata:
MEDICAL HYPOTHESES
fascicolo: 2, volume: 53, anno: 1999,
pagine: 124 - 126
SICI:
0306-9877(199908)53:2<124:PAMOTC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; NITRIC-OXIDE; PREECLAMPSIA; ENDOTHELIUM; PREGNANCY; APOPTOSIS; PHENOTYPE; ADHESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, DW 55 Smyma Powder Springs Rd SE, Marietta, GA 30060 USA 55 Smyma Powder Springs Rd SE Marietta GA USA 30060 A 30060 USA
Citazione:
D.W. Brown, "Pre-eclampsia: a mistake of trophoblastic cells for tumour cells?", MED HYPOTH, 53(2), 1999, pp. 124-126

Abstract

Pre-eclampsia is a severe form of hypertension induced by pregnancy. In pre-eclampsia, there is deficient trophoblast invasion of the spiral arteriesterminating in the placental bed. Perhaps some abnormality occurs in the immunosuppressive process as the maternal immune system encounters paternal antigens expressed by immunosuppressive decidual cells. This immunosuppressive abnormality might cause the deficient trophoblast invasion. Abnormal placentation might then lead to maternal endothelial cell damage by an ongoing process. There might be a recurring sequence of 4 steps: (1) The placenta releases trophoblastic cells with potentially cytotoxic characteristics. These circulating trophoblastic cells have an abnormal pattern of expression of integrins and perhaps other glycoproteins or proteins. (2) The circulating trophoblastic cells loosely bind to maternal endothelial cells, targeting them for anti-tumourigenesis. (3) The maternal immune system reacts against targeted maternal endothelial cells through anti-tumourigenic mechanisms. (4) Widespread maternal endothelial damage causes the characteristic kidney lesioncalled glomerula endotheliosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:28:47