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Titolo:
Successful treatment with fludarabine in two cases of angioimmunoblastic lymphadenopathy with dysproteinemia
Autore:
Hast, R; Jacobsson, B; Petrescu, A; Hjalmar, V;
Indirizzi:
Danderyd Hosp, Div Med, Dept Hematol, Stockholm, Sweden Danderyd Hosp Stockholm Sweden Div Med, Dept Hematol, Stockholm, Sweden
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 34, anno: 1999,
pagine: 597 - 601
SICI:
1042-8194(199908)34:5-6<597:STWFIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-LYMPHOCYTIC-LEUKEMIA; LYMPHOMA STUDY-GROUP; T-CELL LYMPHOMA; CYCLOSPORINE-A; THERAPY;
Keywords:
angioimmunoblastic lymphadenopathy with dysproteinemia; AILD; fludarabine; malignant lymphoma; T-cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Hast, R Karolinska Inst, Danderyd Hosp, Dept Med, Div Hematol, SE-18288 Danderyd, Sweden Karolinska Inst Danderyd Sweden SE-18288 -18288 Danderyd, Sweden
Citazione:
R. Hast et al., "Successful treatment with fludarabine in two cases of angioimmunoblastic lymphadenopathy with dysproteinemia", LEUK LYMPH, 34(5-6), 1999, pp. 597-601

Abstract

Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is today recognized as a T-cell lymphoma which in most cases runs an aggressive course. The diagnosis is often difficult because of the varying clinico-pathological picture. Less than a third of the patients can be expected to have long-term remissions even after multiagent chemotherapy. Complete remissions have been reported after the use of interferon-alpha, cyclosporin A. and recently purine analogues in a few patients. We now report two cases of AILD that had unmaintained remissions for 32 and 10 months, respectively, after fludarabine therapy. In one of the patients fludarabine was used up-front and in the other after she had proved to be resistant to CHOP treatment. No severe infectious complications were noted. The use of purine analogues shouldbe investigated further in AILD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:17:09