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Titolo:
The function of PTB domain proteins
Autore:
Margolis, B; Borg, JP; Straight, S; Meyer, D;
Indirizzi:
Univ Michigan, Med Ctr, Howard Hughes Med Inst, Dept Internal Med & Biol Chem,Sch Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 hem,Sch Med, Ann Arbor, MI 48109 USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 4, volume: 56, anno: 1999,
pagine: 1230 - 1237
SICI:
0085-2538(199910)56:4<1230:TFOPDP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOTYROSINE-BINDING-DOMAIN; AMYLOID PRECURSOR PROTEIN; TYROSINE-PHOSPHORYLATED PROTEINS; SYNAPTIC VESICLE EXOCYTOSIS; ELEGANS VULVAR INDUCTION; INSULIN-RECEPTOR; EPITHELIAL-CELLS; ADAPTER PROTEINS; C-ELEGANS; IN-VIVO;
Keywords:
protein-protein interaction; Shc : X11; protein targeting; Lin-7; Lin-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Margolis, B Univ Michigan, Med Ctr, Howard Hughes Med Inst, Dept Internal Med & Biol Chem,Sch Med, Room 4570,MSRB 2,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan Room 4570,MSRB 2,1150 W Med Ctr Dr Ann Arbor MI USA48109
Citazione:
B. Margolis et al., "The function of PTB domain proteins", KIDNEY INT, 56(4), 1999, pp. 1230-1237

Abstract

Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine-dependent fashion to peptides that form a beta turn. In these proteins, PTB domains play an important role in signal transduction by growth factor receptors. However, in several other proteins, the PTB domains have been found to participate in phosphotyrosine-independent interactions. The X11 family of proteins contains a PTB domain that binds peptides in a phosphotyrosine-independent fashion. The homologue of X11 in C. elegans is the lin-10 gene, a gene crucial for receptor targeting to the basolateral surface of body wall epithelia. The X11/Lin-10 proteins are found in a complex with two other proteins, Lin-2 and Lin-7, which have also been implicated in basolateral targeting in worm epithelia. This protein complex is also likely to be important in the targeting of cell surface proteins in mammalian neurons and epithelia. The ability of the PTB domain to bind peptides ina phosphotyrosine-dependent and -independent fashion allows this domain tobe involved in diverse cellular functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:27:33