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Titolo:
Oxidant-induced apoptosis of glomerular cells: Intracellular signaling andits intervention by bioflavonoid
Autore:
Kitamura, M; Ishikawa, Y;
Indirizzi:
Univ London Univ Coll, Sch Med, Dept Med, Rayne Inst, London WC1E 6JJ, England Univ London Univ Coll London England WC1E 6JJ , London WC1E 6JJ, England
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 4, volume: 56, anno: 1999,
pagine: 1223 - 1229
SICI:
0085-2538(199910)56:4<1223:OAOGCI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
REACTIVE OXYGEN METABOLITES; ACTIVATED PROTEIN-KINASES; MYC-INDUCED APOPTOSIS; RAT MESANGIAL CELLS; HEAT-SHOCK-PROTEIN; NITRIC-OXIDE; TYROSINE PHOSPHORYLATION; TRANSDUCTION PATHWAYS; INITIATED APOPTOSIS; T-CELLS;
Keywords:
reactive oxygen intermediate; apoptosis; quercetin; tyrosine kinase; cell signaling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Kitamura, M Univ London Univ Coll, Sch Med, Dept Med, Rayne Inst, 5 Univ St, London WC1E 6JJ, England Univ London Univ Coll 5 Univ St London EnglandWC1E 6JJ gland
Citazione:
M. Kitamura e Y. Ishikawa, "Oxidant-induced apoptosis of glomerular cells: Intracellular signaling andits intervention by bioflavonoid", KIDNEY INT, 56(4), 1999, pp. 1223-1229

Abstract

Oxidant stress plays a crucial role in the generation of a wide range of glomerular disease. In the first part of this article, we describe intracellular signaling pathways involved in the oxidant-initiated apoptosis of mesangial cells, especially highlighting the tyrosine kinase-c-Jun/AP-1 pathway. In the second part, we address a novel potential of bioflavonoid quercetin as an inhibitor of apoptosis in glomerular cells. Possible mechanisms forthe antiapoptotic action of quercetin and its therapeutic utility are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:20:59