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Titolo:
Comparison of the complete DNA sequences of human herpesvirus 6 variants Aand B
Autore:
Isegawa, Y; Mukai, T; Nakano, K; Kagawa, M; Chen, J; Mori, Y; Sunagawa, T; Kawanishi, K; Sashihara, J; Hata, A; Zou, P; Kosuge, H; Yamanishi, K;
Indirizzi:
Osaka Univ, Med Sch C1, Dept Microbiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 crobiol, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 10, volume: 73, anno: 1999,
pagine: 8053 - 8063
SICI:
0022-538X(199910)73:10<8053:COTCDS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENE; SIMPLEX VIRUS TYPE-1; POLYMERASE CHAIN-REACTION; ORIGIN-BINDING PROTEIN; HUMAN CYTOMEGALOVIRUS; GLYCOPROTEIN-H; NEUTRALIZING EPITOPE; NUCLEOTIDE-SEQUENCE; MONOCLONAL-ANTIBODIES; LYMPHOTROPIC VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Isegawa, Y Osaka Univ, Microbial Dis Res Inst, Dept Virol, 3-1-1 Yamada Oka, Suita, Osaka 5650871, Japan Osaka Univ 3-1-1 Yamada Oka Suita Osaka Japan 5650871 71, Japan
Citazione:
Y. Isegawa et al., "Comparison of the complete DNA sequences of human herpesvirus 6 variants Aand B", J VIROLOGY, 73(10), 1999, pp. 8053-8063

Abstract

Human herpesvirus 6 (HHV-6), which belongs to the betaherpesvirus subfamily and infects mainly T cells in vitro, causes acute and latent infections. Two variants of HHV-6 have been distinguished on the basis of differences in several properties. We have determined the complete DNA sequence of HHV-6variant B (HHV-6B) strain HST, the causative agent of exanthem subitum, and compared the sequence with that of variant A strain U1102. A total of 115potential open reading frames (ORFs) were identified within the 161,573-bpcontiguous sequence of the entire HHV-6 genome, including some genes with remarkable differences in amino acid identity. All genes with <70% identitybetween the two variants were found to contain deleted regions when ORFs that could not be expressed were excluded from the comparison. Except in thecase of U47, these differences were found in immediate-early/regulatory genes, DR2, DR7, U86/90, U89/90, and U95, which may represent characteristic differences of variants A and B. Also, we have successfully typed 14 different strains belonging to variant A or B by PCR using variant-specific primers; the results suggest that the remarkable differences observed were conserved evolutionarily as variant-specific divergence.

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Documento generato il 17/01/21 alle ore 15:53:33