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Titolo:
Comparison of the effects of diazepam on the fear-potentiated startle reflex and the fear-inhibited light reflex in man
Autore:
Bitsios, P; Philpott, A; Langley, RW; Bradshaw, CM; Szabadi, E;
Indirizzi:
Univ Nottingham, Sch Med, Queens Med Ctr, Div Psychiat,Psychopharmacol Sect, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH, Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 13, anno: 1999,
pagine: 226 - 234
SICI:
0269-8811(199909)13:3<226:COTEOD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; CONDITIONED FEAR; PREPULSE INHIBITION; VIETNAM VETERANS; ANXIETY; AMYGDALA; NUCLEUS; CLONIDINE; RESPONSES; PARADIGM;
Keywords:
anxiety; diazepam; fear; light reflex; startle reflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Bradshaw, CM Univ Nottingham, Sch Med, Queens Med Ctr, Div Psychiat,Psychopharmacol Sect, Floor B, Nottingham NG7 2UH, England Univ Nottingham Floor B Nottingham England NG7 2UH , England
Citazione:
P. Bitsios et al., "Comparison of the effects of diazepam on the fear-potentiated startle reflex and the fear-inhibited light reflex in man", J PSYCHOPH, 13(3), 1999, pp. 226-234

Abstract

It has been shown previously that the amplitude of the acoustic startle reflex is enhanced, and the amplitude of the light reflex reduced, when subjects anticipate an aversive event, compared to periods when subjects are resting ('fear-potentiated startle reflex' and 'fear-inhibited light reflex'). We examined whether the anxiolytic diazepam would reverse the effects of threat on the startle and pupillary reflexes. Twelve male volunteers participated in three weekly sessions in which they received oral treatment with placebo, diazepam 5 mg and diazepam 10 mg, according to a balanced crossoverdouble-blind design. One hour after ingestion of the treatments, miotic responses to light pulses and electromyographic responses of the orbicularis oculi muscle to sound pulses were elicited during alternating periods in which the threat of an electric shock (electrodes attached to the subject's wrist) was present (THREAT) and absent (SAFE). The THREAT condition was associated with a significant increase in the amplitude of the electromyographic (EMG) response, a significant reduction of the miotic response amplitude,and an increase in self-rated anxiety. Diazepam attenuated all these effects of THREAT. Diazepam did not affect the amplitude of the miotic response under the SAFE condition, but did suppress the EMG response under this condition. These results confirm the validity of the fear-potentiated startle reflex and fear-inhibited light reflex as laboratory models of human anxiety, and reveal some differences between the effects of diazepam on the two reflexes.

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Documento generato il 05/04/20 alle ore 23:09:39