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Titolo:
Lack of carbachol response indicates the absence of cholinergic receptors in sacs associated with undescended testis
Autore:
Tanyel, FC; Sara, Y; Ertunc, M; Onur, R; Buyukpamukcu, N;
Indirizzi:
Hacettepe Univ, Fac Med, Dept Pediat Surg, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 diat Surg, TR-06100 Ankara, Turkey Hacettepe Univ, Fac Med, Dept Pharmacol, TR-06100 Ankara, Turkey HacettepeUniv Ankara Turkey TR-06100 Pharmacol, TR-06100 Ankara, Turkey
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 9, volume: 34, anno: 1999,
pagine: 1339 - 1344
SICI:
0022-3468(199909)34:9<1339:LOCRIT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; TESTICULAR DESCENT; GENITOFEMORAL NERVE; CREMASTER NUCLEUS; SPINAL NUCLEUS; GUBERNACULUM; RAT; IMMUNOREACTIVITY; CONTRACTILITY; FEMINIZATION;
Keywords:
cryptorchidism; inguinal hernia; hydrocele; hydrocele of the cord; cholinergic receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tanyel, FC Hacettepe Univ, Childrens Hosp, Dept Pediat Surg, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 TR-06100 Ankara, Turkey
Citazione:
F.C. Tanyel et al., "Lack of carbachol response indicates the absence of cholinergic receptors in sacs associated with undescended testis", J PED SURG, 34(9), 1999, pp. 1339-1344

Abstract

Background/Purpose: The mechanism of testicular descent remains controversial. The processus vaginalis (PV) contains smooth muscle and should have contractile activity that may contribute to descent. This study was designed to evaluate the smooth muscle of PVs associated with incomplete obliteration for spontaneous activities and responses to various stimuli, to determineif differences exist according to sex, diagnostic source, or location of the testis. Materials: Peritoneal samples (n = 4); sacs from girls (n = 8) and boys with inguinal hernia (n = 12); and sacs from boys with hydrocele (n = 3), hydrocele of the cord (n = 2), or undescended testis (n = 7) were used for thecurrent study. Tissues were attached to the isometric force displacement transducer in an organ bath containing mammalian Ringer's solution at 37 degrees C, Spontaneous mechanical activity and contractile responses of tissues to the electrical field stimulation, phenylephrine, carbachol, and serotonin were recorded. The values obtained from boys and girls with inguinal hernia and from boys with either undescended or descended testis were compared through Fisher's Exact test. Results: There were no statistically significant differences in patient age between groups. Among the parameters studied, only the carbachol responseof the sacs associated with undescended testis showed a significant difference compared with the others (P =.001). None of the sacs associated with undescended testis responded to carbachol, whereas all of the sacs from boysand girls with inguinal hernia responded to carbachol. Conclusions: Lack of carbachol response suggests the absence of cholinergic receptors within the sacs associated with undescended testis. The lack ofcholinergic receptors may play a role in the failure of the process of testicular descent by hindering either PV elongation into the scrotum or a possible propulsive activity of the PV on the testis. J Pediatr Surg 34:1339-1344. Copyright (C) 1999 by W.B, Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:30:38