Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anatomy of an endogenous antagonist: Relationship between Agouti-related protein and proopiomelanocortin in brain
Autore:
Bagnol, D; Lu, XY; Kaelin, CB; Day, HEW; Ollmann, M; Gantz, I; Akil, H; Barsh, GS; Watson, SJ;
Indirizzi:
Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan Ann ArborMI USA 48109 , Dept Surg, Ann Arbor, MI 48109 USA Howard Hughes Med Inst, Dept Pediat, Stanford, CA 94305 USA Howard Hughes Med Inst Stanford CA USA 94305 diat, Stanford, CA 94305 USA Howard Hughes Med Inst, Dept Genet, Stanford, CA 94305 USA Howard Hughes Med Inst Stanford CA USA 94305 enet, Stanford, CA 94305 USA Univ Aix Marseille 3, CNRS, Marseille 20, France Univ Aix Marseille 3 Marseille France 20 e 3, CNRS, Marseille 20, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 18, volume: 19, anno: 1999,
pagine: NIL_18 - NIL_24
SICI:
0270-6474(19990915)19:18<NIL_18:AOAEAR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING HORMONE; MESSENGER-RNA; IN-VIVO; MELANOCORTIN RECEPTORS; MICE; NUCLEUS; PEPTIDE; CELLS; LOCALIZATION; MELANOTROPIN;
Keywords:
Agouti-related protein; proopiomelanocortin; ingestive behavior; MC3R; MC4R; arcuate nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Watson, SJ Univ Michigan, Mental Hlth Res Inst, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 USA Univ Michigan 205 Zina Pitcher Pl Ann Arbor MI USA 4810909 USA
Citazione:
D. Bagnol et al., "Anatomy of an endogenous antagonist: Relationship between Agouti-related protein and proopiomelanocortin in brain", J NEUROSC, 19(18), 1999, pp. NIL_18-NIL_24

Abstract

Agouti-related protein (AGRP) is a recently discovered orexigenic neuropeptide that inhibits the binding and action of alpha-melanocyte-stimulating hormone derived from proopiomelanocortin (POMC) at the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) and has been proposed to function primarily as an endogenous melanocortin antagonist. To better understand the interplay between the AGRP and melanocortin signaling systems, we compared their nerve fiber distributions with each other by immunohistochemistry and their perikarya distribution with MC3R and MC4R by double in situ hybridization. Although deriving from distinct cell groups, AGRP and melanocortin terminals project to identical brain areas. Both AGRP and melanocortinneurons selectively express the MC3R, which provides a neuroanatomical basis for a dual-input circuit with biological amplification and feedback inhibition. These studies highlight a broader complexity in POMC-mediated behavior in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:46:52