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Titolo:
Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: augmentation by TNF-alpha and IL-1 beta
Autore:
Stoitzner, P; Zanella, M; Ortner, U; Lukas, M; Tagwerker, A; Janke, K; Lutz, MB; Schuler, G; Echtenacher, B; Ryffel, B; Koch, F; Romani, N;
Indirizzi:
Innsbruck Univ, Dept Dermatol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 matol, A-6020 Innsbruck, Austria Univ Erlangen Nurnberg, Dept Dermatol, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany Univ Regensburg, Dept Pathol, D-8400 Regensburg, Germany Univ Regensburg Regensburg Germany D-8400 ol, D-8400 Regensburg, Germany Univ Cape Town, Dept Immunol, ZA-7925 Cape Town, South Africa Univ Cape Town Cape Town South Africa ZA-7925 25 Cape Town, South Africa
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 3, volume: 66, anno: 1999,
pagine: 462 - 470
SICI:
0741-5400(199909)66:3<462:MOLCAD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; ANTIGEN-PRESENTING CELLS; CONTACT HYPERSENSITIVITY; FUNCTIONAL-CHARACTERIZATION; MONOCLONAL-ANTIBODY; DEFICIENT MICE; I RECEPTOR; E-CADHERIN; MATURATION;
Keywords:
lymphatic vessels; inflammatory mediators; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Romani, N Innsbruck Univ, Dept Dermatol, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 ck, Austria
Citazione:
P. Stoitzner et al., "Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: augmentation by TNF-alpha and IL-1 beta", J LEUK BIOL, 66(3), 1999, pp. 462-470

Abstract

Migration from sites of antigen encounter to lymphoid organs is essential to the strong immunogenic function of dendritic cells (DC), In the skin, migration proceeds through dermal lymphatic vessels and is regulated in an incompletely understood way by inflammatory mediators, We studied the effectsof tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in mouse skin organ cultures by direct enumeration of migrating DC and by immunohistochemistry. (1) Neutralizing antibodies to TNF-alpha and IL-1 beta inhibited migration of DC, also in human skin explants (TNF-alpha). (2) TNF-alpha at low concentrations (50 U/mL) anti TL-1 beta (50-3000 U/mL) augmented migration to about 150% of spontaneous migration (3) High concentrations of TNF-alpha (5000 U/mL) inhibited migration by approximately 50%. (4) DC migration from skin explants of TNF-alpha/lymphotoxin-alpha double-deficient mice and TNF-receptor type 1 and 2 double knock out mice was not impaired. (5) TNF-alpha effects were neutralized by anti-IL-1 beta, and vice versa, We conclude that in normal animals both TNF-alpha and IL-1 beta are required for BC migration to occur. In the complete absence of one cytokine(TNF-alpha), however, backup mechanisms step in.

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Documento generato il 01/12/20 alle ore 07:15:16