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Titolo:
Survival, maturation, and function of CD11c(-) and CD11c(+) peripheral blood dendritic cells are differentially regulated by cytokines
Autore:
Kohrgruber, N; Halanek, N; Groger, M; Winter, D; Rappersberger, K; Schmitt-Egenolf, M; Stingl, G; Maurer, D;
Indirizzi:
Univ Vienna, Sch Med, Div Immunol Allergy & Infect Dis, Dept Dermatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Dermatol, A-1090 Vienna, Austria Univ Vienna, Sch Med, Div Gen Dermatol, Dept Dermatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Dermatol, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 163, anno: 1999,
pagine: 3250 - 3259
SICI:
0022-1767(19990915)163:6<3250:SMAFOC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; MATURE; ANTIGEN; IMMATURE; SUBSETS; ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Maurer, D Univ Vienna, Sch Med, Div Immunol Allergy & Infect Dis, Dept Dermatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 tria
Citazione:
N. Kohrgruber et al., "Survival, maturation, and function of CD11c(-) and CD11c(+) peripheral blood dendritic cells are differentially regulated by cytokines", J IMMUNOL, 163(6), 1999, pp. 3250-3259

Abstract

Two types of dendritic cells (DC) are circulating in human blood and can be identified by their differential expression of the myeloid Ag CD11c, In this study, we show that CD11c(-) peripheral blood (PB)-DC correspond to plasmacytoid DC of lymphoid tissue not only by their surface Ag expression profile but, more impressively, by their peculiar uitramorphology, We also demonstrate that CD11c(-) and CD11c(+) DC differ in the quality of their response to and in their requirement for certain cytokines, Freshly isolated CD11c(-) cells depend on IL-3 for survival and use autocrine or exogenous TNF-alpha as maturation signal, leading to the appearance of a highly dendriticphenotype, the up-regulation and redistribution of MHC class II from lysosomal compartments to the plasma membrane, the increased expression of costimulatory molecules, and the switch from a high Ag-processing to a low Ag-processing/potent accessory cell mode. Surprisingly, IL-4 efficiently killed freshly isolated CD11c(-) PB-DC, but did not impair the viability of CD11c() PB-DC and, together with GM-CSF, induced maturation of these cells. A direct functional comparison revealed that neo-Ag-modified and subsequently matured CD11c(-) but to a lesser extent CD11c(+) DC were able to prime naiveAg-specific CD4(+) T cells. Our findings show that two diverse DC types respond to certain T cell-derived cytokines in a differential manner and, thus, suggest that suppression or activation of functionally diverse DC types may be a novel mechanism fur the regulation of the quantity and quality of immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:24:14