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Titolo:
Excessive salt or cholesterol intake alters the balance among endothelium-derived factors released from renal arteries in spontaneously hypertensive rats
Autore:
Kagota, S; Tamashiro, A; Yamaguchi, Y; Nakamura, K; Kunitomo, M;
Indirizzi:
Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ Nishinomiya Hyogo Japan 6638179 Hyogo 6638179, Japan Mukogawa Womens Univ, Interdisciplinary Res Inst Biosci, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ Nishinomiya Hyogo Japan 6638179 Hyogo 6638179, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 4, volume: 34, anno: 1999,
pagine: 533 - 539
SICI:
0160-2446(199910)34:4<533:ESOCIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRO-L-ARGININE; DEPENDENT RELAXATION; PULMONARY-ARTERIES; DAHL RATS; ACETYLCHOLINE; AORTA; HYPERPOLARIZATION; HYPERCHOLESTEROLEMIA; THROMBOXANE-A2; CONTRACTIONS;
Keywords:
endothelium-derived contracting factor (EDCF); endothelium-derived hyperpolarizing factor; (EDHF); high-cholesterol diet; high-salt diet; nitric oxide; spontaneously hypertensive rats (SHRs);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kagota, S Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ 11-68 Koshien Kyuban Cho Nishinomiya Hyogo Japan 6638179
Citazione:
S. Kagota et al., "Excessive salt or cholesterol intake alters the balance among endothelium-derived factors released from renal arteries in spontaneously hypertensive rats", J CARDIO PH, 34(4), 1999, pp. 533-539

Abstract

We investigated the vasorelaxation in renal arteries isolated from spontaneously hypertensive rats (SHRs) fed a basal, a high-sail, or a high-cholesterol diet for 8 weeks. In renal arterial rings from the control group, acetylcholine (ACh)-induced endothelium-dependent relaxations were markedly increased by indomethacin (IND) and ONO-3708, a prostaglandin H-2/thromboxane A(2)-receptor antagonist, but not affected by OKY-046, a thromboxane A, synthetase inhibitor. These increased relaxations were partially inhibited by either NG-nitro-L-arginine methyl ester (L-NAME) or charybdotoxin (CTX), and almost completely abolished by the combination of L-NAME plus CTX. The ACh-induced endothelium-dependent relaxations in the absence of IND were significantly attenuated by the high-salt intake but not affected by the high-cholesterol intake. The degrees of relaxations in the presence of IND were approximately equal among the three diet groups. On the other hand, the relaxations in the presence of IND plus L-NAME were significantly augmented by a high-cholesterol intake and abolished by a high-salt intake, and the relaxations in the presence of IND plus CTX were slightly reduced by a high-cholesterol intake and significantly augmented by a high-salt intake. The production of cyclic guanosine monophosphate (cGMP) in response to ACh was significantly decreased by a high-cholesterol intake and tended to be increasedby a high-salt intake. These findings indicate that in the renal artery ofSHRs, ACh causes production of a sufficient amount of nitric oxide (NO), together with a relaxing factor resembling endothelium-derived hyperpolarizing factors (EDHFs) and also endothelium-derived contracting factors (EDCFs), probably prostaglandin H-2. Our results also suggest that excessive salt intake increases the release of EDCF and NO and decreases that of an EDHF-like factor, whereas excessive cholesterol intake increases release of an EDHF-like factor and decreases that of NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:22:34