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Titolo:
CLADISTIC-ANALYSIS OF DISEASE ASSOCIATION WITH TYROSINE-HYDROXYLASE -APPLICATION TO MANIC-DEPRESSIVE DISEASE AND ALCOHOLISM
Autore:
LOBOS EA; TODD RD;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,CAMPUS BOX 8134,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
American journal of medical genetics
fascicolo: 3, volume: 74, anno: 1997,
pagine: 289 - 295
SICI:
0148-7299(1997)74:3<289:CODAWT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; PHENOTYPIC ASSOCIATIONS; LINKAGE DISEQUILIBRIUM; POLYMORPHISMS; GENE; ILLNESS; LOCUS; CHROMOSOME-11; MARKER; REGION;
Keywords:
GENETICS; BIPOLAR DISORDER; CLADOGRAM; GENE TREE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Lobos e R.D. Todd, "CLADISTIC-ANALYSIS OF DISEASE ASSOCIATION WITH TYROSINE-HYDROXYLASE -APPLICATION TO MANIC-DEPRESSIVE DISEASE AND ALCOHOLISM", American journal of medical genetics, 74(3), 1997, pp. 289-295

Abstract

We evaluated the involvement of tyrosine hydroxylase (TH) mutations in susceptibility to manic-depressive disease (MDD) and alcoholism (ALC) with a cladistics-based association analysis. Eighty-one probands with MDD, 113 probands with alcoholism, and 80 normal controls were tested for differences in frequency of nine haplotypes at the TH locus. The haplotypes were comprised of four restriction fragment length polymorphisms spanning the TH gene. A cladogram constructed from the haplotypes provided the evolutionary context for a nested statistical analysis. Statistically significant evidence was found for association of a subgroup of the sample for each of the disorders with different branches of the gene tree, but the findings were sensitive to minor changes in estimated haplotype frequencies. Am. J. Med. Genet. 74:289-295, 1997. (C) 1997 Wiley-Liss, Inc.

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Documento generato il 11/07/20 alle ore 08:59:28